Literature DB >> 18316188

Potent achiral agonists of the growth hormone secretagogue (ghrelin) receptor. Part 2: Lead optimisation.

Jason Witherington1, Lee Abberley, Michael A Briggs, Katharine Collis, David K Dean, Alessandra Gaiba, N Paul King, Helmut Kraus, Nicola Shuker, Jon G A Steadman, Andrew K Takle, Gareth Sanger, Graham Wadsworth, Sharon Butler, Fiona McKay, Alison Muir, Kim Winborn, Tom D Heightman.   

Abstract

A series of small molecule orally bioavailable ghrelin receptor agonists have been identified through systematic optimisation of a high throughput screening hit.

Entities:  

Mesh:

Substances:

Year:  2007        PMID: 18316188     DOI: 10.1016/j.bmcl.2007.12.021

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  3 in total

1.  Hypotensive effects of ghrelin receptor agonists mediated through a novel receptor.

Authors:  Brid Callaghan; Samin Kosari; Ruslan V Pustovit; Daniela M Sartor; Dorota Ferens; Kung Ban; Jonathan Baell; Trung V Nguyen; Leni R Rivera; James A Brock; John B Furness
Journal:  Br J Pharmacol       Date:  2014-03       Impact factor: 8.739

2.  Ligand-Promoted meta-C-H Amination and Alkynylation.

Authors:  Peng Wang; Gen-Cheng Li; Pankaj Jain; Marcus E Farmer; Jian He; Peng-Xiang Shen; Jin-Quan Yu
Journal:  J Am Chem Soc       Date:  2016-10-13       Impact factor: 15.419

3.  Cognitive enhancing effects of ghrelin receptor agonists.

Authors:  Zeenat Atcha; Woei-Shin Chen; Agnes B Ong; Fong-Kuan Wong; Aveline Neo; Edward R Browne; Jason Witherington; Darrel J Pemberton
Journal:  Psychopharmacology (Berl)       Date:  2009-08-04       Impact factor: 4.530

  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.