| Literature DB >> 18316020 |
Scott L Friedman1, Natalia Nieto.
Abstract
Cannabinoid signaling by CB1 receptors drives fibrogenesis and fat accumulation in liver. A report in this issue of Cell Metabolism (Jeong et al., 2008) now links hepatic stellate cells, a resident liver fibrogenic cell type, to the generation of steatosis through production of the endocannabinoid 2-arachidonoylglycerol (2-AG) after ethanol feeding, leading to paracrine stimulation of hepatocyte CB1 receptors.Entities:
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Year: 2008 PMID： 18316020 DOI： 10.1016/j.cmet.2008.02.002
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287