| Literature DB >> 18314998 |
Alessandro Agosti1, Sebastian Britto, Philippe Renaud.
Abstract
A practical method for the synthesis of gem-2,2-disubstituted tertiary amines from the corresponding lactams (or amides) is reported. It is based on the reaction of thioiminium ions, easily prepared from lactams and amides with organometallic reagents such allylmagnesium, benzylmagnesium, and primary alkylcerium reagents.Entities:
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Year: 2008 PMID： 18314998 DOI： 10.1021/ol800145h
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005