| Literature DB >> 18314154 |
Yi Liu1, Marcel E Curlin, Kurt Diem, Hong Zhao, Ananta K Ghosh, Haiying Zhu, Amanda S Woodward, Janine Maenza, Claire E Stevens, Joanne Stekler, Ann C Collier, Indira Genowati, Wenjie Deng, Rafael Zioni, Lawrence Corey, Tuofu Zhu, James I Mullins.
Abstract
Whether there is selection for specific viral Env variants upon HIV-1 transmission is controversial. We examined the V1V2 and V1V4 regions of Env in 10 new and 8 previously described transmission pairs infected with HIV-1 subtype B, including a total of 9 pairs in which the infecting partner had developed substantial viral diversity prior to transmission. We found that during transmission of HIV-1 subtype B, as well as for other subtypes reported in the past, viral populations in recipients undergo substantial genetic bottlenecks, as well as weak evidence for a propensity to replicate viruses with shorter variable loops and fewer potential N-linked glycosylation sites.Entities:
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Year: 2008 PMID： 18314154 PMCID： PMC2441482 DOI： 10.1016/j.virol.2008.01.029
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616