Literature DB >> 18313798

Empirical characteristics of litigation involving tissue plasminogen activator and ischemic stroke.

Bryan A Liang1, Justin A Zivin.   

Abstract

STUDY
OBJECTIVE: The use of tissue plasminogen activator (tPA) in potential stroke victims by emergency physicians is controversial. One factor that may represent a barrier to use is medicolegal concerns resulting from adverse outcomes. The jury verdicts, settlements, and other adjudications associated with tPA and stroke care are assessed to determine the characteristics of these cases, including whether cases arose from adverse consequences associated with tPA or failure to provide tPA.
METHODS: Using 7 primary jury verdict, settlement, and other adjudication legal databases, lawsuits involving tPA and stroke were collected for analysis of the clinical circumstances of the litigation, the causes of action against providers, the basis for liability, and the presence of emergency physicians and neurologist consultation in the litigation.
RESULTS: Thirty-three cases were found involving tPA ischemic stroke therapy. In 29 (88%) of these cases, patient injury was claimed to have resulted from failure to treat with tPA. Emergency physicians were the most common physician defendants. Defendants prevailed in 21 (64%) cases, and among the 12 with results favorable to the plaintiff, 10 (83%) involved failure to treat and 2 (17%) claimed injury from treatment with tPA.
CONCLUSION: The available evidence concerning litigation involving stroke therapy with tPA indicates liability is predominantly associated with failure to provide tPA, rather than adverse events associated with its use.

Entities:  

Mesh:

Substances:

Year:  2008        PMID: 18313798     DOI: 10.1016/j.annemergmed.2007.12.017

Source DB:  PubMed          Journal:  Ann Emerg Med        ISSN: 0196-0644            Impact factor:   5.721


  9 in total

1.  The birth of neurohospitalists.

Authors:  William D Freeman; S Andrew Josephson
Journal:  Neurohospitalist       Date:  2011-01

2.  Thrombolytic therapy for acute ischemic stroke beyond three hours.

Authors:  Christopher R Carpenter; Samuel M Keim; William Kenneth Milne; William J Meurer; William G Barsan
Journal:  J Emerg Med       Date:  2010-06-25       Impact factor: 1.484

3.  Microbubbles improve sonothrombolysis in vitro and decrease hemorrhage in vivo in a rabbit stroke model.

Authors:  Aliza T Brown; Rene Flores; Eric Hamilton; Paula K Roberson; Michael J Borrelli; William C Culp
Journal:  Invest Radiol       Date:  2011-03       Impact factor: 6.016

Review 4.  The history and future of telestroke.

Authors:  David C Hess; Heinrich J Audebert
Journal:  Nat Rev Neurol       Date:  2013-05-07       Impact factor: 42.937

5.  Legal medicine implications in fibrinolytic therapy of acute ischemic stroke.

Authors:  Monica Sabau; Simona Bungau; Camelia Liana Buhas; Gheorghe Carp; Lucia-Georgeta Daina; Claudia Teodora Judea-Pusta; Bogdan Adrian Buhas; Claudia Maria Jurca; Cristian Marius Daina; Delia Mirela Tit
Journal:  BMC Med Ethics       Date:  2019-10-14       Impact factor: 2.652

6.  To tPA or Not to tPA: Two Medical-Legal Misadventures of Diagnosing a Cerebrovascular Accident as a Stroke Mimic.

Authors:  Malia J Moore; Jonathan Stuart; Alexandra Humphreys; James A Pfaff
Journal:  Clin Pract Cases Emerg Med       Date:  2019-07-08

Review 7.  Medicolegal considerations with intravenous tissue plasminogen activator in stroke: a systematic review.

Authors:  Archit Bhatt; Adnan Safdar; Dhara Chaudhari; Diane Clark; Amber Pollak; Arshad Majid; Mounzer Kassab
Journal:  Stroke Res Treat       Date:  2013-09-04

Review 8.  Current perspectives on the use of intravenous recombinant tissue plasminogen activator (tPA) for treatment of acute ischemic stroke.

Authors:  Sherita N Chapman; Prachi Mehndiratta; Michelle C Johansen; Timothy L McMurry; Karen C Johnston; Andrew M Southerland
Journal:  Vasc Health Risk Manag       Date:  2014-02-24

9.  Anaphylaxis-related Malpractice Lawsuits.

Authors:  Rachel A Lindor; Erika M McMahon; Joseph P Wood; Annie T Sadosty; Eric T Boie; Ronna L Campbell
Journal:  West J Emerg Med       Date:  2018-06-04
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.