In vivo absorption of 14C-glucose and 14C-glycine by the rat intestine during ochratoxin A toxicosis.

Ochratoxin A was administered orally at a dose level of 6 mg/kg/day for eight weeks to rats. Studies on the intestinal cellular macromolecules, activities of membrane bound enzymes and in vivo absorption of 14C-glucose and 14C-glycine exhibited significant alterations. The observed reduction in the absorption of these nutrients during ochratoxin A toxicosis is corroborated by the changes observed in the levels of cellular macromolecules and the activity of membrane bound enzymes which are involved in the transport system.