OBJECTIVE: The purpose of this study was to determine whether gestagen treatment enhances the effects of beta2-mimetics in hormone-induced preterm delivery in pregnant rats in vivo. STUDY DESIGN: Preterm birth was induced with a combination of mifepristone and prostaglandin E2 on day 19 of pregnancy. The animals were treated with salmeterol or gestagens (progesterone or 17alpha-hydroxyprogesterone) or their combination. The treatments were launched on different days (15-18) of pregnancy. The efficacy of treatment was determined in terms of the delivery time counted from the mifepristone injection. RESULTS: Salmeterol treatment delayed premature labor by 2.4 hours, whereas the delay because of the gestagen-salmeterol combinations was more than 5 hours. Progesterone had no effect on the delivery time. CONCLUSION: Parallel treatment with salmeterol and gestagens can be more than twice as effective as salmeterol therapy alone. These results open up a possibility for human trials of combined beta2-agonist-gestagen therapy in threatening preterm delivery.
OBJECTIVE: The purpose of this study was to determine whether gestagen treatment enhances the effects of beta2-mimetics in hormone-induced preterm delivery in pregnant rats in vivo. STUDY DESIGN: Preterm birth was induced with a combination of mifepristone and prostaglandin E2 on day 19 of pregnancy. The animals were treated with salmeterol or gestagens (progesterone or 17alpha-hydroxyprogesterone) or their combination. The treatments were launched on different days (15-18) of pregnancy. The efficacy of treatment was determined in terms of the delivery time counted from the mifepristone injection. RESULTS:Salmeterol treatment delayed premature labor by 2.4 hours, whereas the delay because of the gestagen-salmeterol combinations was more than 5 hours. Progesterone had no effect on the delivery time. CONCLUSION: Parallel treatment with salmeterol and gestagens can be more than twice as effective as salmeterol therapy alone. These results open up a possibility for human trials of combined beta2-agonist-gestagen therapy in threatening preterm delivery.
Authors: Brahm Seymour Coler; Oksana Shynlova; Adam Boros-Rausch; Stephen Lye; Stephen McCartney; Kelycia B Leimert; Wendy Xu; Sylvain Chemtob; David Olson; Miranda Li; Emily Huebner; Anna Curtin; Alisa Kachikis; Leah Savitsky; Jonathan W Paul; Roger Smith; Kristina M Adams Waldorf Journal: J Clin Med Date: 2021-06-29 Impact factor: 4.241
Authors: Shunsuke Hyuga; Robert C Parry; Jennifer Danielsson; Joy Vink; Xiao Wen Fu; Amy Wu; William Dan; Peter D Yim; George Gallos Journal: J Physiol Sci Date: 2021-02-22 Impact factor: 2.257