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Literature DB >> 18313378

A survivor hits the breaks.

Abstract

Bcl2 is the founding member of a family of proteins that regulates apoptosis by controlling mitochondrial outer membrane integrity. In this issue of Molecular Cell, Wang et al. (2008) propose another function for Bcl2: the inhibition of DNA repair by nonhomologous end-joining.

Entities: Gene

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Year: 2008 PMID： 18313378 PMCID： PMC3150556 DOI： 10.1016/j.molcel.2008.02.003

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

9 in total

1. In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability.

Authors: J C Rathmell; M G Vander Heiden; M H Harris; K A Frauwirth; C B Thompson
Journal: Mol Cell Date: 2000-09 Impact factor: 17.970

2. Healing the wounds inflicted by sleeping beauty transposition by double-strand break repair in mammalian somatic cells.

Authors: Zsuzsanna Izsvák; Eva E Stüwe; Dora Fiedler; Andrea Katzer; Penny A Jeggo; Zoltán Ivics
Journal: Mol Cell Date: 2004-01-30 Impact factor: 17.970

1 in total

1. Regulation of nuclear envelope permeability in cell death and survival.

Authors: Christine Strasser; Patricia Grote; Karin Schäuble; Magdalena Ganz; Elisa Ferrando-May
Journal: Nucleus Date: 2012-08-28 Impact factor: 4.197

1 in total

A survivor hits the breaks.

1. In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability.

2. Healing the wounds inflicted by sleeping beauty transposition by double-strand break repair in mammalian somatic cells.

Review 3. Retroviral DNA integration and the DNA damage response.

Review 4. DNA double-strand break repair: all's well that ends well.

5. Bcl2 impedes DNA mismatch repair by directly regulating the hMSH2-hMSH6 heterodimeric complex.

6. The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry.

7. Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer.

Review 8. DNA double-strand break repair and development.

Review 9. Life, death, BH3 profiles, and the salmon mousse.

1. Regulation of nuclear envelope permeability in cell death and survival.