Literature DB >> 18313377

A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis.

Atsushi Tanaka1, Richard J Youle.   

Abstract

DRP1, a member of the dynamin family of large GTPases, mediates mitochondrial fission. In a recent issue of Developmental Cell, Cassidy-Stone et al. (2008) identified mdivi-1, a new DRP1 inhibitor that prevents mitochondria division and Bax-mediated mitochondrial outer membrane permeabilization during apoptosis.

Entities:  

Mesh:

Substances:

Year:  2008        PMID: 18313377     DOI: 10.1016/j.molcel.2008.02.005

Source DB:  PubMed          Journal:  Mol Cell        ISSN: 1097-2765            Impact factor:   17.970


  103 in total

1.  Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction.

Authors:  Ryota Iwasawa; Anne-Laure Mahul-Mellier; Christoph Datler; Evangelos Pazarentzos; Stefan Grimm
Journal:  EMBO J       Date:  2010-12-24       Impact factor: 11.598

2.  Diabetic retinopathy and damage to mitochondrial structure and transport machinery.

Authors:  Qing Zhong; Renu A Kowluru
Journal:  Invest Ophthalmol Vis Sci       Date:  2011-11-07       Impact factor: 4.799

3.  miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1.

Authors:  Jian-Xun Wang; Jian-Qin Jiao; Qian Li; Bo Long; Kun Wang; Jin-Ping Liu; Yan-Rui Li; Pei-Feng Li
Journal:  Nat Med       Date:  2010-12-26       Impact factor: 53.440

Review 4.  Mechanisms of mitochondrial fission and fusion.

Authors:  Alexander M van der Bliek; Qinfang Shen; Sumihiro Kawajiri
Journal:  Cold Spring Harb Perspect Biol       Date:  2013-06-01       Impact factor: 10.005

5.  A pre-microRNA-149 (miR-149) genetic variation affects miR-149 maturation and its ability to regulate the Puma protein in apoptosis.

Authors:  Su-Ling Ding; Jian-Xun Wang; Jian-Qin Jiao; Xin Tu; Qing Wang; Fang Liu; Qian Li; Jie Gao; Qun-Yong Zhou; Dong-Feng Gu; Pei-Feng Li
Journal:  J Biol Chem       Date:  2013-07-19       Impact factor: 5.157

6.  Role of Drp1, a key mitochondrial fission protein, in neuropathic pain.

Authors:  Luiz F Ferrari; Adrienne Chum; Oliver Bogen; David B Reichling; Jon D Levine
Journal:  J Neurosci       Date:  2011-08-03       Impact factor: 6.167

7.  Ischemia-reperfusion Injury in the Brain: Mechanisms and Potential Therapeutic Strategies.

Authors:  Lin L; Wang X; Yu Z
Journal:  Biochem Pharmacol (Los Angel)       Date:  2016-06-20

8.  Transglutaminase 2 ablation leads to mitophagy impairment associated with a metabolic shift towards aerobic glycolysis.

Authors:  F Rossin; M D'Eletto; L Falasca; S Sepe; S Cocco; G M Fimia; M Campanella; P G Mastroberardino; M G Farrace; M Piacentini
Journal:  Cell Death Differ       Date:  2014-07-25       Impact factor: 15.828

9.  The mitochondrial fission factor dynamin-related protein 1 modulates T-cell receptor signalling at the immune synapse.

Authors:  Francesc Baixauli; Noa B Martín-Cófreces; Giulia Morlino; Yolanda R Carrasco; Carmen Calabia-Linares; Esteban Veiga; Juan M Serrador; Francisco Sánchez-Madrid
Journal:  EMBO J       Date:  2011-02-15       Impact factor: 11.598

10.  miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway.

Authors:  Jincheng Li; Stefan Donath; Yanrui Li; Danian Qin; Bellur S Prabhakar; Peifeng Li
Journal:  PLoS Genet       Date:  2010-01-08       Impact factor: 5.917

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.