| Literature DB >> 18313295 |
Francis Giraud1, Cédric Logé, Fabrice Pagniez, Damien Crepin, Patrice Le Pape, Marc Le Borgne.
Abstract
A series of 1-(N-benzylamino)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols 6a-c, 7a-c, 8a, and 9a were prepared in five steps and evaluated for their antifungal activity. The most active compound 7b was docked into a home-made 3D model of the targeted enzyme confirming the importance of Tyr118, His377, and Ser378 residues in its binding mode.Entities:
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Year: 2008 PMID： 18313295 DOI： 10.1016/j.bmcl.2008.02.027
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823