OBJECTIVE: Whether vitamin B6 exerts an independent or a synergic effect in combination with inflammation for the risk of coronary artery disease (CAD) is unclear. The purpose of this study was to investigate whether plasma pyridoxal 5'-phosphate (PLP) is dependent on or independent of the inflammation marker C-reactive protein (CRP) to associate with the risk of CAD. METHODS: This was a hospital-based case-control. Patients were identified with cardiac catheterization as having at least 70% stenosis of one major coronary artery were assigned to the case group (n = 184). The control group (n = 516) was comprised of healthy individuals with normal blood biochemical values. All subjects' height, weight, blood pressure, plasma PLP, homocysteine, high-sensitivity CRP (hs-CRP), and lipid profiles were measured. RESULTS: Plasma PLP concentration was only negatively associated with hs-CRP level in the control group (beta = -0.001, P = 0.03) but not in the CAD or pooled groups. The magnitude of the risk of CAD for low plasma PLP (odds ratio [OR] 2.39) and high hs-CRP (OR 3.37) was very similar. Low plasma PLP concentration combined with low hs-CRP level (OR 2.34) and high plasma PLP concentration combined with high hs-CRP level (OR 3.61) were independently associated with risk for CAD. However, the combined presence of low PLP and higher hs-CRP levels enhanced the risk of CAD and the magnitude was substantially greater (OR 4.35). CONCLUSION: Plasma PLP and hs-CRP are independently associated with an increased risk of CAD, the combined presence of low PLP and high hs-CRP enhanced the risk of CAD, and the magnitude was almost double.
OBJECTIVE: Whether vitamin B6 exerts an independent or a synergic effect in combination with inflammation for the risk of coronary artery disease (CAD) is unclear. The purpose of this study was to investigate whether plasma pyridoxal 5'-phosphate (PLP) is dependent on or independent of the inflammation marker C-reactive protein (CRP) to associate with the risk of CAD. METHODS: This was a hospital-based case-control. Patients were identified with cardiac catheterization as having at least 70% stenosis of one major coronary artery were assigned to the case group (n = 184). The control group (n = 516) was comprised of healthy individuals with normal blood biochemical values. All subjects' height, weight, blood pressure, plasma PLP, homocysteine, high-sensitivity CRP (hs-CRP), and lipid profiles were measured. RESULTS: Plasma PLP concentration was only negatively associated with hs-CRP level in the control group (beta = -0.001, P = 0.03) but not in the CAD or pooled groups. The magnitude of the risk of CAD for low plasma PLP (odds ratio [OR] 2.39) and high hs-CRP (OR 3.37) was very similar. Low plasma PLP concentration combined with low hs-CRP level (OR 2.34) and high plasma PLP concentration combined with high hs-CRP level (OR 3.61) were independently associated with risk for CAD. However, the combined presence of low PLP and higher hs-CRP levels enhanced the risk of CAD and the magnitude was substantially greater (OR 4.35). CONCLUSION: Plasma PLP and hs-CRP are independently associated with an increased risk of CAD, the combined presence of low PLP and high hs-CRP enhanced the risk of CAD, and the magnitude was almost double.
Authors: Vanessa R da Silva; Maria A Ralat; Eoin P Quinlivan; Barbara N DeRatt; Timothy J Garrett; Yueh-Yun Chi; H Frederik Nijhout; Michael C Reed; Jesse F Gregory Journal: Am J Physiol Endocrinol Metab Date: 2014-05-13 Impact factor: 4.310
Authors: Vanessa R da Silva; Luisa Rios-Avila; Yvonne Lamers; Maria A Ralat; Øivind Midttun; Eoin P Quinlivan; Timothy J Garrett; Bonnie Coats; Meena N Shankar; Susan S Percival; Yueh-Yun Chi; Keith E Muller; Per Magne Ueland; Peter W Stacpoole; Jesse F Gregory Journal: J Nutr Date: 2013-08-21 Impact factor: 4.798
Authors: Monika H E Christensen; Dag J Fadnes; Therese H Røst; Eva R Pedersen; John R Andersen; Villy Våge; Arve Ulvik; Øivind Midttun; Per M Ueland; Ottar K Nygård; Gunnar Mellgren Journal: PLoS One Date: 2018-02-05 Impact factor: 3.240
Authors: Lihua Hu; Yuxi Li; Zhihao Liu; Fangfang Fan; Benjamin Xu; Richard Xu; Yun Song; Ping Chen; Yaping Wei; Jia Jia; Long Zhang; Haoyu Weng; Qiuping Shi; Nan Zhang; Xingang Wang; Bo Zheng; Yan Zhang; Jianping Li Journal: Front Cardiovasc Med Date: 2021-12-15