BACKGROUND: The intake of medications is a major aetiologic factor of xerostomia. The purpose of this study was to investigate the selective influence of medication categories on flow rates of individual major salivary glands. METHODS: The effect of each medication category on salivary flow rates was determined by dichotomy comparisons between users and non-users. A total of 246 patients were included, 79 males and 167 females aged 13-92 years (mean 63 years). Of these, 200 used medications, which were grouped according to their category. A comprehensive medical and oral examination was performed. Both unstimulated and stimulated saliva was collected separately from the parotid and submandibular/sublingual glands. RESULTS: Parotid flow rate was decreased among users of tranquillisers and sedatives (unstimulated flow), cardiovascular drugs and gastrointestinal drugs (stimulated flow). Submandibular/sublingual unstimulated output was lower in patients taking cardiovascular drugs, antihistamines, tranquillisers/sedatives and antidepressants, while the stimulated flow, in those taking cardiovascular drugs, antihistamines, tranquillisers/sedatives and gastrointestinal drugs. CONCLUSIONS: Users of many common medication categories display significantly reduced unstimulated and/or stimulated salivary flow rate from the major salivary glands compared with non-users. A larger number of medication categories are associated with reductions in salivary flow rate from submandibular/sublingual glands than parotid glands.
BACKGROUND: The intake of medications is a major aetiologic factor of xerostomia. The purpose of this study was to investigate the selective influence of medication categories on flow rates of individual major salivary glands. METHODS: The effect of each medication category on salivary flow rates was determined by dichotomy comparisons between users and non-users. A total of 246 patients were included, 79 males and 167 females aged 13-92 years (mean 63 years). Of these, 200 used medications, which were grouped according to their category. A comprehensive medical and oral examination was performed. Both unstimulated and stimulated saliva was collected separately from the parotid and submandibular/sublingual glands. RESULTS: Parotid flow rate was decreased among users of tranquillisers and sedatives (unstimulated flow), cardiovascular drugs and gastrointestinal drugs (stimulated flow). Submandibular/sublingual unstimulated output was lower in patients taking cardiovascular drugs, antihistamines, tranquillisers/sedatives and antidepressants, while the stimulated flow, in those taking cardiovascular drugs, antihistamines, tranquillisers/sedatives and gastrointestinal drugs. CONCLUSIONS: Users of many common medication categories display significantly reduced unstimulated and/or stimulated salivary flow rate from the major salivary glands compared with non-users. A larger number of medication categories are associated with reductions in salivary flow rate from submandibular/sublingual glands than parotid glands.
Authors: Gert-Jan van der Putten; Henk S Brand; Luc M J De Visschere; Jos M G A Schols; Cees de Baat Journal: Odontology Date: 2011-12-11 Impact factor: 2.634
Authors: Szilvia Arany; Dorota T Kopycka-Kedzierawski; Thomas V Caprio; Gene E Watson Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Date: 2021-08-29
Authors: Giulio Fortuna; Sarah Whitmire; Kathleen Sullivan; Ivan Alajbeg; Ana Andabak-Rogulj; Anne Marie Lynge Pedersen; Arjan Vissink; Olga di Fede; Massimo Aria; Derk Jan Jager; Jenene Noll; Siri Beier Jensen; Andy Wolff; Michael T Brennan Journal: Clin Oral Investig Date: 2022-10-21 Impact factor: 3.606