| Literature DB >> 1831064 |
J M Khanna1, P H Wu, J Weiner, H Kalant.
Abstract
To test whether N-methyl-D-aspartate (NMDA) receptors have a role in the development of ethanol tolerance, (+)MK-801, an NMDA antagonist, and (-)MK-801, an inactive isomer, were tested in a rapid tolerance paradigm. Results showed that (+)MK-801 blocked the development of rapid tolerance to ethanol in the tilt-plane and hypothermia tests, while (-)MK-801 was ineffective. Neither drug changed the blood ethanol levels in the treated and untreated animals. These data suggest that the known role of NMDA receptors in long-term synaptic facilitation may underlie the effect of learning in the development of tolerance to the motor-impairing and hypothermic effects of ethanol.Entities:
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Year: 1991 PMID： 1831064 DOI： 10.1016/0361-9230(91)90109-w
Source DB: PubMed Journal: Brain Res Bull ISSN： 0361-9230 Impact factor: 4.077