Literature DB >> 18310544

Recurrent cytogenetic findings in subsets of patients with chronic lymphocytic leukemia expressing IgG-switched stereotyped immunoglobulins.

Anastasia Athanasiadou, Kostas Stamatopoulos, Maria Gaitatzi, Niki Stavroyianni, Athanasios Fassas, Achilles Anagnostopoulos.   

Abstract

We report a remarkable association of recurrent (stereotyped) cytogenetic aberrations with two subsets of chronic lymphocytic leukemia (CLL) cases expressing IgG-switched, stereotyped B-cell receptors (BCRs). Comparison with cases with heterogeneous BCRs showed that these recurrent cytogenetic aberrations were subset-biased. These findings further support a role for antigen in CLL development.

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Year:  2008        PMID： 18310544     DOI： 10.3324/haematol.11872

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  12 in total

1.  High-density screening reveals a different spectrum of genomic aberrations in chronic lymphocytic leukemia patients with 'stereotyped' IGHV3-21 and IGHV4-34 B-cell receptors.

Authors:  Millaray Marincevic; Nicola Cahill; Rebeqa Gunnarsson; Anders Isaksson; Mahmoud Mansouri; Hanna Göransson; Markus Rasmussen; Mattias Jansson; Fergus Ryan; Karin Karlsson; Hans-Olov Adami; Fred Davi; Jesper Jurlander; Gunnar Juliusson; Kostas Stamatopoulos; Richard Rosenquist
Journal:  Haematologica       Date:  2010-04-26       Impact factor: 9.941

Review 2.  Molecular and cellular mechanisms of CLL: novel therapeutic approaches.

Authors:  Lisa Pleyer; Alexander Egle; Tanja Nicole Hartmann; Richard Greil
Journal:  Nat Rev Clin Oncol       Date:  2009-06-02       Impact factor: 66.675

3.  Excessive antigen reactivity may underlie the clinical aggressiveness of chronic lymphocytic leukemia stereotyped subset #8.

Authors:  Maria Gounari; Stavroula Ntoufa; Benedetta Apollonio; Nikos Papakonstantinou; Maurilio Ponzoni; Charles C Chu; Davide Rossi; Gianluca Gaidano; Nicholas Chiorazzi; Kostas Stamatopoulos; Paolo Ghia
Journal:  Blood       Date:  2015-04-21       Impact factor: 22.113

Review 4.  Antigen receptor stereotypy in chronic lymphocytic leukemia.

Authors:  K Stamatopoulos; A Agathangelidis; R Rosenquist; P Ghia
Journal:  Leukemia       Date:  2016-11-04       Impact factor: 11.528

5.  Intraclonal cell expansion and selection driven by B cell receptor in chronic lymphocytic leukemia.

Authors:  Monica Colombo; Giovanna Cutrona; Daniele Reverberi; Sonia Fabris; Antonino Neri; Marina Fabbi; Giovanni Quintana; Giovanni Quarta; Fabio Ghiotto; Franco Fais; Manlio Ferrarini
Journal:  Mol Med       Date:  2011-04-28       Impact factor: 6.354

6.  Somatic hypermutation profiles in stereotyped IGHV4-34 receptors from South American chronic lymphocytic leukemia patients.

Authors:  Carmen Stanganelli; Davi Coe Torres; Claudia Ortega; María Elena Márquez; Victoria Remedi; Juana Cabrera; Claudia Mardaraz; Camila Galvano; Andrea Krzywinski; Cecilia Lang; Lorena Zanella; Evangelina Agriello; Raimundo Bezares; Astrid Pavlovsky; Miguel A Pavlovsky; Pablo Oppezzo; Irma Slavutsky
Journal:  Ann Hematol       Date:  2021-10-28       Impact factor: 4.030

7.  Distinct transcriptional control in major immunogenetic subsets of chronic lymphocytic leukemia exhibiting subset-biased global DNA methylation profiles.

Authors:  Meena Kanduri; Millaray Marincevic; Anna M Halldórsdóttir; Larry Mansouri; Katarina Junevik; Stavroula Ntoufa; Hanna Göransson Kultima; Anders Isaksson; Gunnar Juliusson; Per-Ola Andersson; Hans Ehrencrona; Kostas Stamatopoulos; Richard Rosenquist
Journal:  Epigenetics       Date:  2012-11-15       Impact factor: 4.528

8.  Temporal dynamics of clonal evolution in chronic lymphocytic leukemia with stereotyped IGHV4-34/IGKV2-30 antigen receptors: longitudinal immunogenetic evidence.

Authors:  Lesley-Ann Sutton; Efterpi Kostareli; Evangelia Stalika; Athanasios Tsaftaris; Achilles Anagnostopoulos; Nikos Darzentas; Richard Rosenquist; Kostas Stamatopoulos
Journal:  Mol Med       Date:  2013-08-28       Impact factor: 6.354

9.  Relevance of stereotyped B-cell receptors in the context of the molecular, cytogenetic and clinical features of chronic lymphocytic leukemia.

Authors:  Francesco Maura; Giovanna Cutrona; Sonia Fabris; Monica Colombo; Giacomo Tuana; Luca Agnelli; Serena Matis; Marta Lionetti; Massimo Gentile; Anna Grazia Recchia; Francesco Di Raimondo; Caterina Musolino; Fiorella Ilariucci; Nicola Di Renzo; Emanuela Pesce; Stefano Molica; Massimo Federico; Agostino Cortelezzi; Fortunato Morabito; Manlio Ferrarini; Antonino Neri
Journal:  PLoS One       Date:  2011-08-29       Impact factor: 3.240

Review 10.  Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance.

Authors:  Michele Dal-Bo; Francesco Bertoni; Francesco Forconi; Antonella Zucchetto; Riccardo Bomben; Roberto Marasca; Silvia Deaglio; Luca Laurenti; Dimitar G Efremov; Gianluca Gaidano; Giovanni Del Poeta; Valter Gattei
Journal:  J Transl Med       Date:  2009-08-28       Impact factor: 5.531
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