Literature DB >> 18310540

Cytokines in combination to treat radiation-induced myelosuppresssion: evaluation of SCF + glycosylated EPO + pegylated G-CSF as an emergency treatment in highly irradiated monkeys.

Michel Drouet, Christophe Delaunay, Nancy Grenier, Philippe Garrigou, Jean-François Mayol, Francis Hérodin.   

Abstract

Multicytokine therapy may be useful to counteract radiation-induced myelosuppression. We assessed the stem cell factor + glycosylated erythropoietin + pegylated granulocyte colony-stimulating factor combination (SEG) as an emergency treatment. SEG in highly irradiated monkeys efficacy appeared to be restricted to granulopoiesis. Early administration of Erythropoietin did not prevent radiation-induced anemia.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18310540     DOI： 10.3324/haematol.12183

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  10 in total

1.  Mobilization of CD34+ progenitor cells in association with decreased proliferation in the bone marrow of macaques after administration of the Fms-like tyrosine kinase 3 ligand.

Authors:  R Keith Reeves; Qing Wei; Patricia N Fultz
Journal:  Clin Vaccine Immunol       Date:  2010-06-16

2.  Rat Models of Partial-body Irradiation with Bone Marrow-sparing (Leg-out PBI) Designed for FDA Approval of Countermeasures for Mitigation of Acute and Delayed Injuries by Radiation.

Authors:  Brian L Fish; Thomas J MacVittie; Feng Gao; Jayashree Narayanan; Tracy Gasperetti; Dana Scholler; Yuri Sheinin; Heather A Himburg; Barry Hart; Meetha Medhora
Journal:  Health Phys       Date:  2021-10-01       Impact factor: 2.922

3.  The Natural History of Acute Radiation-induced H-ARS and Concomitant Multi-organ Injury in the Non-human Primate: The MCART Experience.

Authors:  Ann M Farese; Catherine Booth; Greg L Tudor; Wanchang Cui; Eric P Cohen; George A Parker; Kim G Hankey; Thomas J MacVittie
Journal:  Health Phys       Date:  2021-10-01       Impact factor: 2.922

4.  Agonist of the adenosine A3 receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of γ-irradiated mice.

Authors:  Michal Hofer; Milan Pospíšil; Ladislav Dušek; Zuzana Hoferová; Denisa Komůrková
Journal:  Radiat Environ Biophys       Date:  2013-11-22       Impact factor: 1.925

5.  PEGylated G-CSF (BBT-015), GM-CSF (BBT-007), and IL-11 (BBT-059) analogs enhance survival and hematopoietic cell recovery in a mouse model of the hematopoietic syndrome of the acute radiation syndrome.

Authors:  Paul Artur Plett; Hui Lin Chua; Carol H Sampson; Barry P Katz; Christine M Fam; Lana J Anderson; George N Cox; Christie M Orschell
Journal:  Health Phys       Date:  2014-01       Impact factor: 1.316

6.  Survival efficacy of the PEGylated G-CSFs Maxy-G34 and neulasta in a mouse model of lethal H-ARS, and residual bone marrow damage in treated survivors.

Authors:  Hui Lin Chua; P Artur Plett; Carol H Sampson; Barry P Katz; Gilbert W Carnathan; Thomas J MacVittie; Keith Lenden; Christie M Orschell
Journal:  Health Phys       Date:  2014-01       Impact factor: 1.316

7.  The Effect of Radiation Dose and Variation in Neupogen® Initiation Schedule on the Mitigation of Myelosuppression during the Concomitant GI-ARS and H-ARS in a Nonhuman Primate Model of High-dose Exposure with Marrow Sparing.

Authors:  Thomas J MacVittie; Alexander W Bennett; Ann M Farese; Cheryl Taylor-Howell; Cassandra P Smith; Allison M Gibbs; Karl Prado; William Jackson
Journal:  Health Phys       Date:  2015-11       Impact factor: 2.922

Review 8.  Acute radiation syndrome caused by accidental radiation exposure - therapeutic principles.

Authors:  Harald Dörr; Viktor Meineke
Journal:  BMC Med       Date:  2011-11-25       Impact factor: 8.775

Review 9.  Comments on the mechanisms of action of radiation protective agents: basis components and their polyvalence.

Authors:  Mikhail V Vasin
Journal:  Springerplus       Date:  2014-08-07

Review 10.  Combining Pharmacological Countermeasures to Attenuate the Acute Radiation Syndrome-A Concise Review.

Authors:  Michal Hofer; Zuzana Hoferová; Daniel Depeš; Martin Falk
Journal:  Molecules       Date:  2017-05-19       Impact factor: 4.411
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.