Literature DB >> 183101

Interaction of aminoacyl-tRNA synthetases and tRNA: positive and negative cooperativity of their active centres.

E G Malygin, V V Zinoviev, F Fasiolo, L L Kisselev, L L Kochkina, V Z Achverdyan.   

Abstract

The influence of tRNA on the kinetics of PP-ATP exchange and aminoacyl-tRNA formation catalysed by leucyl-, phenylalanyl-, and tryptophanyl-tRNA synthetases has been investigated. These enzymes were chosen because they belong to three main classes of quaternary structure alpha1, alpha2beta2 and alpha2, respectively. The present paper shows that the investigated synthetases manifest kinetic cooperativity of the active centres which is negative in the case of AAA formation and positive in the case of leucyl- and tryptophanyl-tRNA synthesis. The obtained data were interpreted with the aid of the trigger model of the enzyme.

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Year:  1976        PMID： 183101     DOI： 10.1007/bf00356933

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  15 in total

1.  The amino acid activation reaction catalyzed by methionyl-transfer rna synthetase: evidence for synergistic coupling between the sites for methionine adenosine and pyrophosphate.

Authors:  S Blanquet; G Fayat; J P Waller
Journal:  J Mol Biol       Date:  1975-05-05       Impact factor: 5.469

2.  Kinetic mechanism of the [32P] ATP-PPi exchange reaction catalysed by yeast phenylalanyl-tRNA synthetase.

Authors:  L L Kisselev; F Fasiolog
Journal:  FEBS Lett       Date:  1975-11-15       Impact factor: 4.124

Review 3.  Aminoacyl-tRNA synthetases: sone recent results and achievements.

Authors:  L L Kisselev; O O Favorova
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1974

Review 4.  The mechanism of aminoacylation of transfer RNA.

Authors:  R B Loftfield
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1972

5.  Beef pancreas tryptophanyl-tRNA synthetase. Order of substrate binding in ATP-(32-P)-pyrophosphate exchange reaction.

Authors:  D G Knorre; E G Malygin; M G Slinko; V I Timoshenko; V V Zinoviev; L L Kisselev; L L Kochkina; O O Favorova
Journal:  Biochimie       Date:  1974       Impact factor: 4.079

6.  [Truptophanyl tRNA synthetase. Isolation and characterization of the 2 enzyme forms].

Authors:  O O Favorova; L L Khochkina; M Shaĭgo; A V Parin; S H Khil'ko; V S Prasolov; L L Kiselev
Journal:  Mol Biol       Date:  1974 Sep-Oct       Impact factor: 1.374

7.  Demonstration of two active sites on a monomeric aminoacyl-tRNA synthetase. Possible roles of negative cooperativity and half-of-the-sites reactivity in oligomeric enzymes.

Authors:  A R Fersht
Journal:  Biochemistry       Date:  1975-01-14       Impact factor: 3.162

8.  Leucyl-tRNA synthetase. Mechanism of leucyl-tRNA formation.

Authors:  P Rouget; F Chapeville
Journal:  Eur J Biochem       Date:  1971-12-10

9.  Yeast phenylalanyl-tRNA synthetase. Stoichiometry of the phenylalanyl adenylate-enzyme complex and transfer of phenylalanine from this complex to tRNA-PHE.

Authors:  F Fasiolo; J P Ebel
Journal:  Eur J Biochem       Date:  1974-11-01

10.  Peptide mapping of aminoacyl-tRNA synthetases: evidence for internal sequence homology in Escherichia coli leucyl-tRNA synthetase.

Authors:  R M Waterson; W H Konigsberg
Journal:  Proc Natl Acad Sci U S A       Date:  1974-02       Impact factor: 11.205
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  2 in total

1.  Yeast seryl tRNA synthetase: two sets of substrate sites involved in aminoacylation.

Authors:  U Pachmann; H G Zachau
Journal:  Nucleic Acids Res       Date:  1978-03       Impact factor: 16.971

2.  Towards an Integrative Understanding of tRNA Aminoacylation-Diet-Host-Gut Microbiome Interactions in Neurodegeneration.

Authors:  Elena L Paley; George Perry
Journal:  Nutrients       Date:  2018-03-26       Impact factor: 5.717
  2 in total

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