Literature DB >> 18309425

Formal total synthesis of triptolide.

Natalie A Miller1, Anthony C Willis, Michael S Sherburn.   

Abstract

A new approach to the medicinally-important natural product triptolide is significantly shorter than previous syntheses, highly convergent and avoids the use of protecting groups; key features include two Diels-Alder reactions and a new deoxygenative aromatisation process.

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Year:  2008        PMID： 18309425     DOI： 10.1039/b718754h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

Review 1.  The main anticancer bullets of the Chinese medicinal herb, thunder god vine.

Authors:  Zi Liu; Liang Ma; Guang-Biao Zhou
Journal:  Molecules       Date:  2011-06-23       Impact factor: 4.411

2.  Catalytic Asymmetric Formal Total Synthesis of (-)-Triptophenolide and (+)-Triptolide.

Authors:  Wen-Dan Xu; Liang-Qun Li; Ming-Ming Li; Hui-Chun Geng; Hong-Bo Qin
Journal:  Nat Prod Bioprospect       Date:  2016-04-20

Review 3.  A review of the total syntheses of triptolide.

Authors:  Xiang Zhang; Zaozao Xiao; Hongtao Xu
Journal:  Beilstein J Org Chem       Date:  2019-08-22       Impact factor: 2.883

4.  A general synthesis of dendralenes.

Authors:  Josemon George; Jas S Ward; Michael S Sherburn
Journal:  Chem Sci       Date:  2019-09-12       Impact factor: 9.825
  4 in total

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