Literature DB >> 18309318

Daptomycin use in infants: report of two cases with peak and trough drug concentrations.

M Cohen-Wolkowiez1, P B Smith, D K Benjamin, V G Fowler, K C Wade.   

Abstract

We report two infants treated with daptomycin for methicillin-resistant Staphylococcus aureus infection and describe peak and trough blood concentrations measured during therapy. The peak concentrations were 41.7 and 36.7 mcg ml(-1), and the 12-hour trough concentrations were 12.7 and 16.3 mcg ml(-1), respectively. Even though the infants received higher doses than adults, their drug concentrations were comparable to those observed in adults treated with regular dosing of daptomycin.

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Year:  2008        PMID： 18309318      PMCID： PMC2752140          DOI： 10.1038/sj.jp.7211898

Source DB:  PubMed          Journal:  J Perinatol        ISSN： 0743-8346            Impact factor:   2.521


  1 in total

1.  Daptomycin pharmacokinetics and safety following administration of escalating doses once daily to healthy subjects.

Authors:  Barry H Dvorchik; David Brazier; Michael F DeBruin; Robert D Arbeit
Journal:  Antimicrob Agents Chemother       Date:  2003-04       Impact factor: 5.191
  1 in total
  14 in total

1.  Serum levels of daptomycin in pediatric patients.

Authors:  C Antachopoulos; E Iosifidis; K Sarafidis; F Bazoti; E Gikas; A Katragkou; V Drossou-Agakidou; E Roilides
Journal:  Infection       Date:  2012-01-21       Impact factor: 3.553

2.  The Use of Daptomycin and Linezolid to Treat Vancomycin-Intermediate Staphylococcus haemolyticus Infection in a Premature Infant.

Authors:  Kalen B Porter; Bethany Lynch; Chitra S Mani
Journal:  J Pediatr Pharmacol Ther       Date:  2010-10

3.  Pharmacokinetics and tolerability of single-dose daptomycin in young infants.

Authors:  Michael Cohen-Wolkowiez; Kevin M Watt; Christoph P Hornik; Daniel K Benjamin; P Brian Smith
Journal:  Pediatr Infect Dis J       Date:  2012-09       Impact factor: 2.129

4.  The Use of Daptomycin to Treat Methicillin-Resistant Staphylococcus Epidermidis Bacteremia in a Critically Ill Child with Renal Failure.

Authors:  Stephen Morris; Kate Gould; Lee P Ferguson
Journal:  J Pediatr Pharmacol Ther       Date:  2017 Jul-Aug

5.  Successful Use of Daptomycin in a Preterm Neonate With Persistent Methicillin-Resistant Staphylococcus epidermidis Bacteremia.

Authors:  Kristen M Gawronski
Journal:  J Pediatr Pharmacol Ther       Date:  2015 Jan-Feb

6.  Daptomycin Pharmacokinetics in Adolescents Undergoing Hemodialysis and Peritoneal Dialysis: A Case Series With Pharmacokinetic Modeling.

Authors:  Sin Yin Lim; Teresa Lewis; Sukyung Woo; Martin Turman; David W A Bourne; Michael E Burton; Pornpimol Rianthavorn
Journal:  J Pediatr Pharmacol Ther       Date:  2021-02-15

7.  European ST80 community-associated methicillin-resistant Staphylococcus aureus orbital cellulitis in a neonate.

Authors:  Evangelia E Tsironi; Fani Zacharaki; Ioanna N Grivea; Sophia V Tachmitzi; Aspasia N Michoula; Marianna Vlychou; Efthimia Petinaki; George A Syrogiannopoulos
Journal:  BMC Ophthalmol       Date:  2012-05-15       Impact factor: 2.209

8.  Methicillin-Resistant Staphylococcus aureus Endovascular Infection in a Neonate: Prolonged, Safe, and Effective Use of Daptomycin and Enoxaparin.

Authors:  Joshua I Chan; Asif Noor; Christie Clauss; Renu Aggarwal; Amrita Nayak
Journal:  J Pediatr Pharmacol Ther       Date:  2020 Jan-Feb

Review 9.  Clinical Pharmacokinetics of Daptomycin.

Authors:  Nicolas Gregoire; Alexia Chauzy; Julien Buyck; Blandine Rammaert; William Couet; Sandrine Marchand
Journal:  Clin Pharmacokinet       Date:  2020-12-14       Impact factor: 6.447

10.  Dosing antibiotics in neonates: review of the pharmacokinetic data.

Authors:  Nazario D Rivera-Chaparro; Michael Cohen-Wolkowiez; Rachel G Greenberg
Journal:  Future Microbiol       Date:  2017-07-31       Impact factor: 3.553
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