| Literature DB >> 18309287 |
Jinhee Bae1, Deokbum Park, Yun-Sil Lee, Dooil Jeoung.
Abstract
Interleukin-2 plays a significant role in T cell proliferation. Here, we report the role of IL-2 in angiogenesis. IL-2 increased the ROS level and phosphorylation of Akt in human umbilical vein endothelial cells (HUVECs). IL-2 increased angiogenesis in an animal model and tube formation in HUVECs. The effect of IL-2 on angiogenesis and tube formation was mediated by ROS and Akt. This is the first report that IL-2 promotes angiogenesis.Entities:
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Year: 2008 PMID： 18309287
Source DB: PubMed Journal: J Microbiol Biotechnol ISSN： 1017-7825 Impact factor: 2.351