| Literature DB >> 18305402 |
Abstract
Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and ET-3) were added to HN33 (mouse hippocampal neuron chi neuroblastoma) cells. Among the three types of ET, only ET-1 increased the intracellular calcium levels in a PLC dependent manner with the induction of ERK 1/2 activation. As the result of ET-1 exposure, the survival rate of HN33 cells and the PKCalpha translocation into the plasma membrane were increased. We suggest that ET-1 participated in the neuroprotective effect involving the calcium-PKCalpha-ERK1/2 pathway.Entities:
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Year: 2008 PMID： 18305402 PMCID： PMC2679316 DOI： 10.3858/emm.2008.40.1.92
Source DB: PubMed Journal: Exp Mol Med ISSN： 1226-3613 Impact factor: 8.718