Literature DB >> 18305398

Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-alpha by inhibiting activation of NF-kappaB.

Tae Wook Kyung1, Ji Eun Lee, Hyun Hee Shin, Hye Seon Choi.   

Abstract

Rutin, a glycoside of flavonol, inhibits osteoclast formation induced by receptor activator of NF-kappaB ligand (RANKL) in bone marrow-derived macrophages. It reduces reactive oxygen species produced by RANKL and its inhibitory effect results from reduced levels of TNF-alpha. Rutin also lowers NF-kappaB activation in response to RANKL.

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Year:  2008        PMID： 18305398      PMCID： PMC2679321          DOI： 10.3858/emm.2008.40.1.52

Source DB:  PubMed          Journal:  Exp Mol Med        ISSN： 1226-3613            Impact factor:   8.718


  25 in total

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3.  Association between oxidative stress and bone mineral density.

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4.  Mechanism of inhibitory effects of chelating drugs on lipid peroxidation in rat brain homogenates.

Authors:  A B Kozlov; E A Ostrachovitch; I B Afanas'ev
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8.  Different antioxidant activities of bioflavonoid rutin in normal and iron-overloading rats.

Authors:  I B Afanas'ev; E A Ostrachovitch; N E Abramova; L G Korkina
Journal:  Biochem Pharmacol       Date:  1995-08-25       Impact factor: 5.858

9.  Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

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  21 in total

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Review 8.  Impact of air pollutants on oxidative stress in common autophagy-mediated aging diseases.

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Review 9.  Molecular signaling mechanisms behind polyphenol-induced bone anabolism.

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10.  Solanum nigrum Line inhibits osteoclast differentiation and suppresses bone mineral density reduction in the ovariectomy‑induced osteoporosis model.

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