Literature DB >> 18305106

Detection of Histoplasma capsulatum antigenuria by ultrafiltration of samples with false-negative results.

Lindsey Egan1, Patricia A Connolly, Deanna Fuller, Thomas E Davis, John Witt, Kenneth S Knox, Chadi A Hage, L Joseph Wheat.   

Abstract

Patients with histoplasmosis may test falsely negative for Histoplasma capsulatum antigenuria. In some cases antigen is present at levels below the assay's detection limit, and ultrafiltration could improve sensitivity. Antigen was detected following ultrafiltration in 73.8% of falsely negative specimens versus 2% of controls. Ultrafiltration improved sensitivity with a small reduction in specificity.

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Year:  2008        PMID： 18305106      PMCID： PMC2292670          DOI： 10.1128/CVI.00493-07

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  3 in total

1.  Diagnosis of pulmonary histoplasmosis and blastomycosis by detection of antigen in bronchoalveolar lavage fluid using an improved second-generation enzyme-linked immunoassay.

Authors:  Chadi A Hage; Thomas E Davis; Lindsey Egan; Michelle Parker; Deanna Fuller; Ann M Lemonte; Michelle Durkin; Patricia Connelly; L Joseph Wheat; Deborah Blue-Hnidy; Kenneth S Knox
Journal:  Respir Med       Date:  2006-06-06       Impact factor: 3.415

2.  Detection of histoplasma antigen by a quantitative enzyme immunoassay.

Authors:  Patricia A Connolly; Michelle M Durkin; Ann M Lemonte; Emily J Hackett; L Joseph Wheat
Journal:  Clin Vaccine Immunol       Date:  2007-10-03

3.  Diagnosis of coccidioidomycosis by antigen detection using cross-reaction with a Histoplasma antigen.

Authors:  Tim Kuberski; Robert Myers; L Joseph Wheat; Michelle Durkin; Patricia Connolly; Bernard M Kubak; David Bruckner; David Pegues
Journal:  Clin Infect Dis       Date:  2007-01-25       Impact factor: 9.079
  3 in total
  4 in total

1.  False-negative Histoplasma antigen in acute pulmonary histoplasmosis: the value of urinary concentration by ultrafiltration and heat denaturation of serum proteins in detection of Histoplasma antigen.

Authors:  Ashok Srinivasan; Martin B Kleiman; Larisa Debelenko; Dennis C Stokes; John De Vincenzo; Joseph L Wheat
Journal:  Pediatr Infect Dis J       Date:  2009-05       Impact factor: 2.129

2.  Improved detection of Histoplasma antigenemia following dissociation of immune complexes.

Authors:  S Swartzentruber; A LeMonte; J Witt; D Fuller; T Davis; C Hage; P Connolly; M Durkin; L J Wheat
Journal:  Clin Vaccine Immunol       Date:  2009-01-14

3.  Development and evaluation of an enzyme-linked immunosorbent assay to detect Histoplasma capsulatum antigenuria in immunocompromised patients.

Authors:  Christina M Scheel; Blanca Samayoa; Alejandro Herrera; Mark D Lindsley; Lynette Benjamin; Yvonne Reed; John Hart; Sandra Lima; Blanca E Rivera; Gabriella Raxcaco; Tom Chiller; Eduardo Arathoon; Beatriz L Gómez
Journal:  Clin Vaccine Immunol       Date:  2009-04-08

4.  Antigen negative gastrointestinal histoplasmosis in an AIDS patient.

Authors:  Betsy Escobar; Victoria N Maldonado; Sofia Ansari; Juan C Sarria
Journal:  Am J Case Rep       Date:  2014-02-26
  4 in total

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