Literature DB >> 18304834

LPS/TLR4 signal transduction pathway.

Yong-Chen Lu1, Wen-Chen Yeh2, Pamela S Ohashi3.   

Abstract

The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in the past few years. Here we review molecules involved in TLR4-mediated signaling, including players that are involved in the negative regulation of this important pathway.

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Year:  2008        PMID： 18304834     DOI： 10.1016/j.cyto.2008.01.006

Source DB:  PubMed          Journal:  Cytokine        ISSN： 1043-4666            Impact factor:   3.861


  918 in total

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