| Literature DB >> 18304813 |
Laurent Désaubry1, Stéphanie Riché, Patricia Laeuffer, Jean-Pierre Cazenave.
Abstract
We have conjugated tirofiban, an antagonist of the GPIIb/IIIa integrin receptor, to PEG, and shown that these polymers effectively inhibit platelet aggregation. This inhibition decreased with the size of the polymer. Our goal was to develop new cryoprotective agents to store frozen platelets. Surprisingly, tirofiban-conjugated PEG did not exhibit any protection.Entities:
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Year: 2008 PMID： 18304813 DOI： 10.1016/j.bmcl.2008.01.118
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823