Literature DB >> 18304791

Screening for cytotoxic activity of extracts and isolated alkaloids from bulbs of Hippeastrum vittatum.

A F S Silva1, J P de Andrade, K R B Machado, A B Rocha, M A Apel, M E G Sobral, A T Henriques, J A S Zuanazzi.   

Abstract

The dichloromethane and n-butanol extracts obtained from fresh bulbs of Hippeastrum vittatum (Amaryllidaceae), collected in Southern Brazil, were evaluated for their cytotoxic activity in vitro against five human cell lines (HT29 colon adenocarcinoma, H460 non-small cell lung carcinoma, RXF393 renal cell carcinoma, MCF7 breast cancer, and OVCAR3 epithelial ovarian cancer), using the sulphorhodamine B assay. Both extracts showed potential antiproliferative activity. From CH(2)Cl(2) fraction, three alkaloids were isolated: lycorine, vittatine and montanine. The two last compounds were submitted to the antiproliferative assay and the highest level of cytotoxicity was found for the alkaloid montanine.

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Year:  2008        PMID： 18304791     DOI： 10.1016/j.phymed.2007.12.001

Source DB:  PubMed          Journal:  Phytomedicine        ISSN： 0944-7113            Impact factor:   5.340


  7 in total

1.  Synthetic analogues of the montanine-type alkaloids with activity against apoptosis-resistant cancer cells.

Authors:  Karthik Govindaraju; Aude Ingels; Md Nabiul Hasan; Dandan Sun; Veronique Mathieu; Marco Masi; Antonio Evidente; Alexander Kornienko
Journal:  Bioorg Med Chem Lett       Date:  2018-02-02       Impact factor: 2.823

2.  Bulbispermine: a crinine-type Amaryllidaceae alkaloid exhibiting cytostatic activity toward apoptosis-resistant glioma cells.

Authors:  Giovanni Luchetti; Robert Johnston; Véronique Mathieu; Florence Lefranc; Kathryn Hayden; Anna Andolfi; Delphine Lamoral-Theys; Mary R Reisenauer; Cody Champion; Stephen C Pelly; Willem A L van Otterlo; Igor V Magedov; Robert Kiss; Antonio Evidente; Snezna Rogelj; Alexander Kornienko
Journal:  ChemMedChem       Date:  2012-03-02       Impact factor: 3.466

3.  Hippeastrum reticulatum (Amaryllidaceae): Alkaloid Profiling, Biological Activities and Molecular Docking.

Authors:  Luciana R Tallini; Edison H Osorio; Vanessa Dias Dos Santos; Warley de Souza Borges; Marcel Kaiser; Francesc Viladomat; José Angelo S Zuanazzi; Jaume Bastida
Journal:  Molecules       Date:  2017-12-09       Impact factor: 4.411

Review 4.  Chemical and Biological Aspects of Montanine-Type Alkaloids Isolated from Plants of the Amaryllidaceae Family.

Authors:  Darja Koutová; Negar Maafi; Radim Havelek; Lubomír Opletal; Gerald Blunden; Martina Řezáčová; Lucie Cahlíková
Journal:  Molecules       Date:  2020-05-16       Impact factor: 4.411

5.  The complete chloroplast genome of Hippeastrum vittatum (Amaryllidaceae).

Authors:  Peiling Li; Maofei Ren; Qingsong Zhu; Yan Zhang; Hanbing Xu; Zhiyong Wang; Songhu Liu; Qin Cheng; Benguo Liang
Journal:  Mitochondrial DNA B Resour       Date:  2020-10-09       Impact factor: 0.658

6.  Antioxidant and cytotoxic activities of three species of tropical seaweeds.

Authors:  Yin Yin Chia; M S Kanthimathi; Kong Soo Khoo; Jayakumar Rajarajeswaran; Hwee Ming Cheng; Wai Sum Yap
Journal:  BMC Complement Altern Med       Date:  2015-09-29       Impact factor: 3.659

7.  The use of bio-guided fractionation to explore the use of leftover biomass in Dutch flower bulb production as allelochemicals against weeds.

Authors:  Dinar S C Wahyuni; Frank van der Kooy; Peter G L Klinkhamer; Rob Verpoorte; Kirsten Leiss
Journal:  Molecules       Date:  2013-04-17       Impact factor: 4.411
  7 in total

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