OBJECTIVE: To evaluate the presence of antisperm antibodies in testicular cancer patients 1 month after orchiectomy and before radiotherapy or chemotherapy. DESIGN: Clinical study. SETTING: Department of andrology and seminology at a university hospital. PATIENT(S): One hundred ninety patients with testicular cancer. INTERVENTION(S): Determination of semen parameters and autoimmune reaction evaluated on the sperm surface and in blood serum. MAIN OUTCOME MEASURE(S): Autoimmune reaction on the sperm surface by the direct immunobead test (IBT), and in blood serum by the indirect IBT and the gelatin agglutination test (GAT), was evaluated 1 month after orchiectomy and before beginning chemotherapy or radiotherapy. RESULT(S): Of the 190 patients, 11 (5.8%) were positive for antisperm antibody by GAT. On indirect IBT, 3 of the 11 GAT-positive patients were positive to IgG class only, with values of 22%, 24%, and 40%. Of the 11 GAT-positive patients, 4 showed no antibody bound to the sperm surface, and 3 were positive to IgG class only (28%, 21%, and 38%), with binding exclusively on the tail. Direct IBT could not be performed in the remaining 4 patients. CONCLUSION(S): Our data support the hypothesis that testicular cancer might not be a possible cause of antisperm autoimmunization and infertility.
OBJECTIVE: To evaluate the presence of antisperm antibodies in testicular cancerpatients 1 month after orchiectomy and before radiotherapy or chemotherapy. DESIGN: Clinical study. SETTING: Department of andrology and seminology at a university hospital. PATIENT(S): One hundred ninety patients with testicular cancer. INTERVENTION(S): Determination of semen parameters and autoimmune reaction evaluated on the sperm surface and in blood serum. MAIN OUTCOME MEASURE(S): Autoimmune reaction on the sperm surface by the direct immunobead test (IBT), and in blood serum by the indirect IBT and the gelatin agglutination test (GAT), was evaluated 1 month after orchiectomy and before beginning chemotherapy or radiotherapy. RESULT(S): Of the 190 patients, 11 (5.8%) were positive for antisperm antibody by GAT. On indirect IBT, 3 of the 11 GAT-positive patients were positive to IgG class only, with values of 22%, 24%, and 40%. Of the 11 GAT-positive patients, 4 showed no antibody bound to the sperm surface, and 3 were positive to IgG class only (28%, 21%, and 38%), with binding exclusively on the tail. Direct IBT could not be performed in the remaining 4 patients. CONCLUSION(S): Our data support the hypothesis that testicular cancer might not be a possible cause of antisperm autoimmunization and infertility.
Authors: A Ferlin; A E Calogero; C Krausz; F Lombardo; D Paoli; R Rago; C Scarica; M Simoni; C Foresta; V Rochira; E Sbardella; S Francavilla; G Corona Journal: J Endocrinol Invest Date: 2022-01-24 Impact factor: 4.256
Authors: Francesco Pallotti; Sandro C Esteves; Fabiana Faja; Alessandra Buonacquisto; Anna Chiara Conflitti; Maria Neve Hirsch; Andrea Lenzi; Donatella Paoli; Francesco Lombardo Journal: Endocrine Date: 2022-10-19 Impact factor: 3.925
Authors: Valeriy A Chereshnev; Svetlana V Pichugova; Yakov B Beikin; Margarita V Chereshneva; Angelina I Iukhta; Yuri I Stroev; Leonid P Churilov Journal: Pathophysiology Date: 2021-10-15
Authors: D Paoli; F Pallotti; A Anzuini; S Bianchini; L Caponecchia; A Carraro; M R Ciardi; F Faja; C Fiori; D Gianfrilli; A Lenzi; M Lichtner; I Marcucci; C M Mastroianni; G Nigro; P Pasculli; C Pozza; F Rizzo; P Salacone; A Sebastianelli; F Lombardo Journal: J Endocrinol Invest Date: 2022-08-09 Impact factor: 5.467
Authors: F Faja; F Finocchi; T Carlini; F Rizzo; F Pallotti; M Spaziani; G Balercia; A Lenzi; D Paoli; F Lombardo Journal: J Endocrinol Invest Date: 2021-03-04 Impact factor: 4.256