| Literature DB >> 18304494 |
You-Qiang Song1, Kenneth M C Cheung, Daniel W H Ho, Sandy C S Poon, Kazuhiro Chiba, Yoshiharu Kawaguchi, Yuichiro Hirose, Mauro Alini, Sibylle Grad, Anita F Y Yee, John C Y Leong, Keith D K Luk, Shea-Ping Yip, Jaro Karppinen, Kathryn S E Cheah, Pak Sham, Shiro Ikegawa, Danny Chan.
Abstract
Lumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18304494 PMCID： PMC2427233 DOI： 10.1016/j.ajhg.2007.12.017
Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025