AIMS: To compare the predictive value of inflammatory biomarkers and lipids for vascular and non-vascular mortality in older men. METHODS AND RESULTS: The relevance of inflammatory biomarkers and lipids for vascular and non-vascular mortality was assessed in a prospective study of 5360 men (mean age 77 years) followed for 7 years. Vascular mortality was positively associated with log C-reactive protein (lnCRP), fibrinogen and total/HDL-C (high-density lipoprotein cholesterol), and inversely associated with albumin [age adjusted hazard ratio (HR) per 2-SD higher usual level (approximately the difference between the top and the bottom thirds of the distribution): 2.09 for lnCRP; 1.70 for fibrinogen; 0.50 for albumin and 1.45 for total/HDL-C]. The associations with the inflammatory markers were attenuated after adjustment for established risk factors, including lipids [adjusted HRs: 1.86 (lnCRP); 1.44 (fibrinogen); 0.51 (albumin)], and further attenuated (and, for fibrinogen, no longer predictive) after adjustment for each other [fully adjusted HRs: 1.60 (lnCRP); 1.01 (fibrinogen); 0.61 (albumin)]. Higher CRP and lower albumin levels were also associated with significantly raised non-vascular mortality independently of other characteristics [fully adjusted HRs: 1.62 (lnCRP); 0.65 (albumin)]. CONCLUSION: In this cohort of older men, higher CRP and lower albumin levels strongly predicted both vascular and non-vascular mortality, independently of other characteristics.
AIMS: To compare the predictive value of inflammatory biomarkers and lipids for vascular and non-vascular mortality in older men. METHODS AND RESULTS: The relevance of inflammatory biomarkers and lipids for vascular and non-vascular mortality was assessed in a prospective study of 5360 men (mean age 77 years) followed for 7 years. Vascular mortality was positively associated with log C-reactive protein (lnCRP), fibrinogen and total/HDL-C (high-density lipoprotein cholesterol), and inversely associated with albumin [age adjusted hazard ratio (HR) per 2-SD higher usual level (approximately the difference between the top and the bottom thirds of the distribution): 2.09 for lnCRP; 1.70 for fibrinogen; 0.50 for albumin and 1.45 for total/HDL-C]. The associations with the inflammatory markers were attenuated after adjustment for established risk factors, including lipids [adjusted HRs: 1.86 (lnCRP); 1.44 (fibrinogen); 0.51 (albumin)], and further attenuated (and, for fibrinogen, no longer predictive) after adjustment for each other [fully adjusted HRs: 1.60 (lnCRP); 1.01 (fibrinogen); 0.61 (albumin)]. Higher CRP and lower albumin levels were also associated with significantly raised non-vascular mortality independently of other characteristics [fully adjusted HRs: 1.62 (lnCRP); 0.65 (albumin)]. CONCLUSION: In this cohort of older men, higher CRP and lower albumin levels strongly predicted both vascular and non-vascular mortality, independently of other characteristics.
Authors: Yi Zhai; Xiao Ming Shi; Simon Michael Fitzgerald; Han Zhu Qian; Virginia B Kraus; Melanie Sereny; Perry Hu; Zhao Xue Yin; Jian Wei Xu; Yi Zeng Journal: Biomed Environ Sci Date: 2012-06 Impact factor: 3.118
Authors: Neil Murphy; Robert Carreras-Torres; Mingyang Song; Andrew T Chan; Richard M Martin; Nikos Papadimitriou; Niki Dimou; Konstantinos K Tsilidis; Barbara Banbury; Kathryn E Bradbury; Jelena Besevic; Sabina Rinaldi; Elio Riboli; Amanda J Cross; Ruth C Travis; Claudia Agnoli; Demetrius Albanes; Sonja I Berndt; Stéphane Bézieau; D Timothy Bishop; Hermann Brenner; Daniel D Buchanan; N Charlotte Onland-Moret; Andrea Burnett-Hartman; Peter T Campbell; Graham Casey; Sergi Castellví-Bel; Jenny Chang-Claude; María-Dolores Chirlaque; Albert de la Chapelle; Dallas English; Jane C Figueiredo; Steven J Gallinger; Graham G Giles; Stephen B Gruber; Andrea Gsur; Jochen Hampe; Heather Hampel; Tabitha A Harrison; Michael Hoffmeister; Li Hsu; Wen-Yi Huang; Jeroen R Huyghe; Mark A Jenkins; Temitope O Keku; Tilman Kühn; Sun-Seog Kweon; Loic Le Marchand; Christopher I Li; Li Li; Annika Lindblom; Vicente Martín; Roger L Milne; Victor Moreno; Polly A Newcomb; Kenneth Offit; Shuji Ogino; Jennifer Ose; Vittorio Perduca; Amanda I Phipps; Elizabeth A Platz; John D Potter; Conghui Qu; Gad Rennert; Lori C Sakoda; Clemens Schafmayer; Robert E Schoen; Martha L Slattery; Catherine M Tangen; Cornelia M Ulrich; Franzel J B van Duijnhoven; Bethany Van Guelpen; Kala Visvanathan; Pavel Vodicka; Ludmila Vodickova; Veronika Vymetalkova; Hansong Wang; Emily White; Alicja Wolk; Michael O Woods; Anna H Wu; Wei Zheng; Ulrike Peters; Marc J Gunter Journal: Gastroenterology Date: 2019-12-27 Impact factor: 22.682
Authors: Pengfei Zhu; William G Herrington; Richard Haynes; Jonathan Emberson; Martin J Landray; Cathie L M Sudlow; Mark Woodward; Colin Baigent; Sarah Lewington; Natalie Staplin Journal: J Am Soc Nephrol Date: 2020-10-30 Impact factor: 10.121
Authors: Stephen Kaptoge; Emanuele Di Angelantonio; Gordon Lowe; Mark B Pepys; Simon G Thompson; Rory Collins; John Danesh Journal: Lancet Date: 2009-12-22 Impact factor: 79.321