| Literature DB >> 1830237 |
K Saito1, S P Markey, M P Heyes.
Abstract
Chronic infections are associated with increased concentrations of the neuroactive kynurenine pathway metabolite, quinolinic acid (QUIN), in blood and cerebrospinal fluid. In the present study, repeated injections of gamma-interferon (5000 IU, every 3 days for 39 days) to C57BL6 mice were associated with persistent activation of indoleamine-2,3-dioxygenase (IDO), the first enzyme of the kynurenine pathway, in lung and brain, sustained increases in brain QUIN concentration and increases in plasma L-kynurenine and QUIN levels. Mice chronically treated with gamma-interferon offer an animal model to investigate the effects of sustained immune stimulation on kynurenine pathway metabolism.Entities:
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Year: 1991 PMID： 1830237 DOI： 10.1016/0006-8993(91)91171-v
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252