BACKGROUND: Laryngeal adenoid cystic carcinoma (ACC) is a rare disease. We reviewed our experience at the Princess Margaret Hospital (PMH) with its treatment. METHODS: This is a retrospective chart review of 15 cases treated at PMH between 1963 and 2005. RESULTS: The mean age was 48.6 years. There was no sex predilection. The subglottis was the most common subsite involved. Only 2 patients had regional metastasis. Local or regional recurrence was noted in 5 patients (33.3%). The distant metastasis rate was 66.7% and involved the lungs. The median follow-up time was 6.9 years. The 5- and 10-year overall and disease-specific survival rates were 64% and 46%, and 69% and 49%, respectively. CONCLUSION: Laryngeal ACC is a rare disease with a high rate of distant recurrence. Its management should emphasize maximizing local and regional disease control by surgery followed by radiotherapy with distant disease failure eventually dictating survival.
BACKGROUND: Laryngeal adenoid cystic carcinoma (ACC) is a rare disease. We reviewed our experience at the Princess Margaret Hospital (PMH) with its treatment. METHODS: This is a retrospective chart review of 15 cases treated at PMH between 1963 and 2005. RESULTS: The mean age was 48.6 years. There was no sex predilection. The subglottis was the most common subsite involved. Only 2 patients had regional metastasis. Local or regional recurrence was noted in 5 patients (33.3%). The distant metastasis rate was 66.7% and involved the lungs. The median follow-up time was 6.9 years. The 5- and 10-year overall and disease-specific survival rates were 64% and 46%, and 69% and 49%, respectively. CONCLUSION: Laryngeal ACC is a rare disease with a high rate of distant recurrence. Its management should emphasize maximizing local and regional disease control by surgery followed by radiotherapy with distant disease failure eventually dictating survival.
Authors: Andrés Coca-Pelaz; Leon Barnes; Alessandra Rinaldo; Antonio Cardesa; Jatin P Shah; Juan P Rodrigo; Carlos Suárez; Jean Anderson Eloy; Justin A Bishop; Kenneth O Devaney; Lester D R Thompson; Bruce M Wenig; Primož Strojan; Marc Hamoir; Patrick J Bradley; Douglas R Gnepp; Carl E Silver; Pieter J Slootweg; Asterios Triantafyllou; Vincent Vander Poorten; Michelle D Williams; Alena Skálová; Henrik Hellquist; Afshin Teymoortash; Jesus E Medina; K Thomas Robbins; Karen T Pitman; Luiz P Kowalski; Remco de Bree; William M Mendenhall; Robert P Takes; Alfio Ferlito Journal: Adv Ther Date: 2016-03-19 Impact factor: 3.845