Literature DB >> 1830196

Single-dose trospectomycin for chlamydial urethritis in men.

M C Keefer1, M A Menegus, M A Nasello, J A Reid, M Long, R C Reichman.   

Abstract

Trospectomycin is an aminocyclitol analog of spectinomycin with significant in vitro activity against Chlamydia trachomatis. A single 1-g intramuscular dose was administered to 10 men with symptomatic, culture-positive chlamydial urethritis. Trospectomycin was well tolerated but failed to eradicate chlamydial infection, as determined by cultures obtained approximately 1 week after treatment.

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Year:  1991        PMID： 1830196      PMCID： PMC245141          DOI： 10.1128/AAC.35.5.986

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

Review 1.  Susceptibility testing of Chlamydia trachomatis: from eggs to monoclonal antibodies.

Authors:  J M Ehret; F N Judson
Journal:  Antimicrob Agents Chemother       Date:  1988-09       Impact factor: 5.191

2.  In vitro antibacterial activity of trospectomycin (U-63366F), a novel spectinomycin analog.

Authors:  G E Zurenko; B H Yagi; J J Vavra; B B Wentworth
Journal:  Antimicrob Agents Chemother       Date:  1988-02       Impact factor: 5.191

3.  Isolation of Chlamydia trachomatis from men with urethritis: relative value of one vs. two swabs and influence of concomitant gonococcal infection.

Authors:  S S Singal; R C Reichman; P S Graman; C Greisberger; M A Trupei; M A Menegus
Journal:  Sex Transm Dis       Date:  1986 Jan-Mar       Impact factor: 2.830

Review 4.  Chlamydial infections (third of three parts).

Authors:  J Schachter
Journal:  N Engl J Med       Date:  1978-03-09       Impact factor: 91.245

5.  The lack of effect of ampicillin plus probenecid given for genital infections with Neisseria gonorrhoeae on associated infections with Chlamydia trachomatis.

Authors:  J D Oriel; G L Ridgway; P Reeve; D C Beckingham; J Owen
Journal:  J Infect Dis       Date:  1976-05       Impact factor: 5.226

6.  Treatment of gonococcal urethritis in men with a rifampicin-erythromycin combination.

Authors:  J D Oriel; G L Ridgway; D Goldmeier; D Felmingham
Journal:  Sex Transm Dis       Date:  1982 Oct-Dec       Impact factor: 2.830

7.  Effect of short term treatment of non-gonococcal urethritis with minocycline.

Authors:  D Taylor-Robinson; R T Evans; E D Coufalik; J K Oates
Journal:  Genitourin Med       Date:  1986-02

8.  Effect of amoxicillin on simultaneous Chlamydia trachomatis infection in men with gonococcal urethritis: comparison of three dosage regimens.

Authors:  P A Csángó; T Gundersen; I M Martinsen
Journal:  Sex Transm Dis       Date:  1985 Apr-Jun       Impact factor: 2.830

9.  Treatment of Neisseria gonorrhoeae infections in men with single-dose thiamphenicol.

Authors:  J D Oriel; P Loo; D Felmingham
Journal:  Sex Transm Dis       Date:  1984 Oct-Dec       Impact factor: 2.830

10.  Fleroxacin versus standard therapy in gonococcal urethritis.

Authors:  A Lassus; O V Renkonen; J Ellmén
Journal:  J Antimicrob Chemother       Date:  1988-10       Impact factor: 5.790
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