UNLABELLED: Among community-dwelling older men, compared to those without Parkinson's disease (PD), over approximately 5 years, those with baseline PD had a significantly greater rate of annualized total hip bone loss (-1.1% vs. 0.4%), proportion of incident non-spine fractures (14.9% vs. 7.2%) and mortality (34.8% vs. 9.5%). INTRODUCTION: The objective of this study was to examine the association of Parkinson's disease (PD) with bone loss and fractures in older men. METHODS: This prospective cohort study analyzed data from 5,937 community dwelling men aged >or=65 years at six clinical centers of the Osteoporotic Fractures in Men (MrOS) Study. At baseline and visit two (mean interval 4.6 +/-0.4 SD years), community-diagnosed PD was ascertained by self-report and hip bone mineral density (BMD) was measured using dual energy x-ray absorptiometry (DXA). Incident fractures were self-reported. Fractures and deaths were centrally adjudicated. RESULTS: At baseline, 46 (0.8%) men had PD. Age-adjusted mean annualized total hip bone loss was greater in men with vs. those without PD (-1.08% vs. -0.36%, p < 0.001). 15.2% of men with PD and 7.2% of men without PD experienced an incident non-spine fracture (age-adjusted HR 2.4, 95%CI 1.1-5.0). 34.8% of men with PD and 9.5% of men without PD died during follow-up (age-adjusted HR 3.5, 95%CI 2.2-5.5). Associations of PD with bone loss, fractures and mortality were modestly altered by additional individual adjustment for possible confounders. CONCLUSIONS: In community-dwelling older men, PD was associated with increased bone loss, fractures and mortality. In addition to implementing fall prevention measures, clinicians should consider osteoporosis screening in older men with PD.
UNLABELLED: Among community-dwelling older men, compared to those without Parkinson's disease (PD), over approximately 5 years, those with baseline PD had a significantly greater rate of annualized total hip bone loss (-1.1% vs. 0.4%), proportion of incident non-spine fractures (14.9% vs. 7.2%) and mortality (34.8% vs. 9.5%). INTRODUCTION: The objective of this study was to examine the association of Parkinson's disease (PD) with bone loss and fractures in older men. METHODS: This prospective cohort study analyzed data from 5,937 community dwelling men aged >or=65 years at six clinical centers of the Osteoporotic Fractures in Men (MrOS) Study. At baseline and visit two (mean interval 4.6 +/-0.4 SD years), community-diagnosed PD was ascertained by self-report and hip bone mineral density (BMD) was measured using dual energy x-ray absorptiometry (DXA). Incident fractures were self-reported. Fractures and deaths were centrally adjudicated. RESULTS: At baseline, 46 (0.8%) men had PD. Age-adjusted mean annualized total hip bone loss was greater in men with vs. those without PD (-1.08% vs. -0.36%, p < 0.001). 15.2% of men with PD and 7.2% of men without PD experienced an incident non-spine fracture (age-adjusted HR 2.4, 95%CI 1.1-5.0). 34.8% of men with PD and 9.5% of men without PD died during follow-up (age-adjusted HR 3.5, 95%CI 2.2-5.5). Associations of PD with bone loss, fractures and mortality were modestly altered by additional individual adjustment for possible confounders. CONCLUSIONS: In community-dwelling older men, PD was associated with increased bone loss, fractures and mortality. In addition to implementing fall prevention measures, clinicians should consider osteoporosis screening in older men with PD.
Authors: J A Grisso; J L Kelsey; B L Strom; G Y Chiu; G Maislin; L A O'Brien; S Hoffman; F Kaplan Journal: N Engl J Med Date: 1991-05-09 Impact factor: 91.245
Authors: Eric Orwoll; Janet Babich Blank; Elizabeth Barrett-Connor; Jane Cauley; Steven Cummings; Kristine Ensrud; Cora Lewis; Peggy M Cawthon; Robert Marcus; Lynn M Marshall; Joan McGowan; Kathy Phipps; Sherry Sherman; Marcia L Stefanick; Katie Stone Journal: Contemp Clin Trials Date: 2005-10 Impact factor: 2.226
Authors: Howard A Fink; Michael A Kuskowski; Eric S Orwoll; Jane A Cauley; Kristine E Ensrud Journal: J Am Geriatr Soc Date: 2005-09 Impact factor: 5.562
Authors: Brent C Taylor; Pamela J Schreiner; Katie L Stone; Howard A Fink; Steven R Cummings; Michael C Nevitt; Paula J Bowman; Kristine E Ensrud Journal: J Am Geriatr Soc Date: 2004-09 Impact factor: 5.562
Authors: Ludmila N Bakhireva; Elizabeth Barrett-Connor; Donna Kritz-Silverstein; Deborah J Morton Journal: Am J Prev Med Date: 2004-06 Impact factor: 5.043
Authors: Mayetri Gupta; Ching-Lung Cheung; Yi-Hsiang Hsu; Serkalem Demissie; L Adrienne Cupples; Douglas P Kiel; David Karasik Journal: J Bone Miner Res Date: 2011-06 Impact factor: 6.741
Authors: Camille P Vaughan; Alayne D Markland; Phillip P Smith; Kathryn L Burgio; George A Kuchel Journal: J Am Geriatr Soc Date: 2017-12-04 Impact factor: 5.562
Authors: Camille P Vaughan; Kathryn L Burgio; Patricia S Goode; Jorge L Juncos; Gerald McGwin; Lisa Muirhead; Alayne D Markland; Theodore M Johnson Journal: Neurourol Urodyn Date: 2019-06-11 Impact factor: 2.696
Authors: Hind A Beydoun; May A Beydoun; Nishant K Mishra; Ola S Rostant; Alan B Zonderman; Shaker M Eid Journal: Parkinsonism Relat Disord Date: 2016-11-19 Impact factor: 4.891