Monica R Walker1, Thaddeus S Stappenbeck. 1. Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA.
Abstract
PURPOSE OF REVIEW: Study of developmental signaling pathways suggests that the intestinal stem cell niche regulates the activity of the crypt-based epithelial progenitors during homeostasis and injury states. The cellular origin of these signals, however, remains poorly defined. Here, we examine the current state of knowledge regarding intestinal epithelial progenitor niches and highlight applicable lessons learned from other systems. RECENT FINDINGS: Cell-cell contact, regulatory factor delivery, stem cell polarity, and mesenchymal stem cells are considered. SUMMARY: Based on the findings in other niche systems as well as the overall complexity and unique organization of the intestinal progenitor niche, future studies will focus on defining peri-cryptal architecture, cellular sources of regulatory factors, and the dynamic nature of the niche during homeostasis and injury repair. These insights may lead to novel cell-based therapies for a variety of conditions that damage the mucosal lining of the gut.
PURPOSE OF REVIEW: Study of developmental signaling pathways suggests that the intestinal stem cell niche regulates the activity of the crypt-based epithelial progenitors during homeostasis and injury states. The cellular origin of these signals, however, remains poorly defined. Here, we examine the current state of knowledge regarding intestinal epithelial progenitor niches and highlight applicable lessons learned from other systems. RECENT FINDINGS: Cell-cell contact, regulatory factor delivery, stem cell polarity, and mesenchymal stem cells are considered. SUMMARY: Based on the findings in other niche systems as well as the overall complexity and unique organization of the intestinal progenitor niche, future studies will focus on defining peri-cryptal architecture, cellular sources of regulatory factors, and the dynamic nature of the niche during homeostasis and injury repair. These insights may lead to novel cell-based therapies for a variety of conditions that damage the mucosal lining of the gut.
Authors: Marie-Pier Tetreault; Yizeng Yang; Jenna Travis; Qian-Chun Yu; Andres Klein-Szanto; John W Tobias; Jonathan P Katz Journal: Gastroenterology Date: 2010-03-27 Impact factor: 22.682
Authors: Monica R Walker; Sarah L Brown; Terrence E Riehl; William F Stenson; Thaddeus S Stappenbeck Journal: J Biol Chem Date: 2009-12-14 Impact factor: 5.157