OBJECTIVE: CYP4A11, a member of the cytochrome P450 family, acts mainly as an enzyme that converts arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite involved in blood pressure regulation in humans. Disruption of the murine cyp4a14 and cyp4a10 genes, homologues of human CYP4A11, was reported recently to cause hypertension. The gene-disrupted male mice had higher blood pressure than the gene-disrupted female mice. The present study aimed to assess the association between the human CYP4A11 gene and essential hypertension, using a haplotype-based case-control study including separate analysis of the gender groups. METHODS: The 304 essential hypertension patients and 207 age-matched control individuals were genotyped for three single-nucleotide polymorphisms of the human CYP4A11 gene (rs2269231, rs1126742, rs9333025). Data were assessed for three separate groups: total participants, men and women. RESULTS: For total participants, the genotypic distribution of rs1126742 differed significantly between the two groups (P = 0.005). For total participants, men and women, the recessive model (CC versus TC + TT) of rs1126742 differed significantly between the two groups (P = 0.007, P = 0.043, and P = 0.045, respectively). Logistic regression analysis showed the TC + TT genotype was significantly higher in essential hypertension patients than in control individuals for total participants and men (P = 0.022 and P = 0.043, respectively). The A-T-G haplotype frequency (established by rs2269231, rs1126742, rs9333025) was significantly higher in essential hypertension men than in control men (P = 0.043). CONCLUSIONS: Essential hypertension is associated with the TC + TT genotype of rs1126742 in the human CYP4A11 gene. The A-T-G haplotype appears a useful genetic marker of essential hypertension in Japanese men.
OBJECTIVE:CYP4A11, a member of the cytochrome P450 family, acts mainly as an enzyme that converts arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite involved in blood pressure regulation in humans. Disruption of the murinecyp4a14 and cyp4a10 genes, homologues of humanCYP4A11, was reported recently to cause hypertension. The gene-disrupted male mice had higher blood pressure than the gene-disrupted female mice. The present study aimed to assess the association between the humanCYP4A11 gene and essential hypertension, using a haplotype-based case-control study including separate analysis of the gender groups. METHODS: The 304 essential hypertensionpatients and 207 age-matched control individuals were genotyped for three single-nucleotide polymorphisms of the humanCYP4A11 gene (rs2269231, rs1126742, rs9333025). Data were assessed for three separate groups: total participants, men and women. RESULTS: For total participants, the genotypic distribution of rs1126742 differed significantly between the two groups (P = 0.005). For total participants, men and women, the recessive model (CC versus TC + TT) of rs1126742 differed significantly between the two groups (P = 0.007, P = 0.043, and P = 0.045, respectively). Logistic regression analysis showed the TC + TT genotype was significantly higher in essential hypertensionpatients than in control individuals for total participants and men (P = 0.022 and P = 0.043, respectively). The A-T-G haplotype frequency (established by rs2269231, rs1126742, rs9333025) was significantly higher in essential hypertensionmen than in control men (P = 0.043). CONCLUSIONS: Essential hypertension is associated with the TC + TT genotype of rs1126742 in the humanCYP4A11 gene. The A-T-G haplotype appears a useful genetic marker of essential hypertension in Japanese men.
Authors: Albert W Dreisbach; Stanley V Smith; Patrick B Kyle; Manjunath Ramaiah; Margaret Amenuke; Michael R Garrett; Seth T Lirette; Michael E Griswold; Richard J Roman Journal: Prostaglandins Other Lipid Mediat Date: 2014-08-22 Impact factor: 3.072
Authors: James V Gainer; Michael S Lipkowitz; Chang Yu; Michael R Waterman; Elliott P Dawson; Jorge H Capdevila; Nancy J Brown Journal: J Am Soc Nephrol Date: 2008-04-02 Impact factor: 10.121
Authors: Ana C Dordea; Sara Vandenwijngaert; Victor Garcia; Robert E T Tainsh; Daniel I Nathan; Kaitlin Allen; Michael J Raher; Laurel T Tainsh; Fan Zhang; Wolfgang S Lieb; Sarah Mikelman; Andrew Kirby; Christine Stevens; Robrecht Thoonen; Allyson G Hindle; Patrick Y Sips; John R Falck; Mark J Daly; Peter Brouckaert; Kenneth D Bloch; Donald B Bloch; Rajeev Malhotra; Michal L Schwartzman; Emmanuel S Buys Journal: Am J Physiol Heart Circ Physiol Date: 2016-05-03 Impact factor: 4.733
Authors: Uzen Savas; Daniel E W Machemer; Mei-Hui Hsu; Pryce Gaynor; Jerome M Lasker; Robert H Tukey; Eric F Johnson Journal: J Biol Chem Date: 2009-04-14 Impact factor: 5.157