BACKGROUND: Several dietary factors have been associated with risk of amyotrophic lateral sclerosis (ALS) in case-control studies, but no prospective studies have investigated diet and ALS. METHODS: We prospectively assessed the association of selected foods and beverages with ALS mortality among participants of the Cancer Prevention Study II, a cohort of over 1 million men and women enrolled in 1982. Habitual diet was assessed with a 44-item food frequency questionnaire. Participant follow-up was conducted from 1989 through 2002 for ALS mortality. RESULTS: During the follow-up period, 862 cohort participants died of ALS. The strongest finding was an inverse association between chicken consumption and risk of ALS (P for trend = 0.0006). We also observed an increased risk of ALS among study participants with a high consumption of brown rice/whole wheat/barley (P for trend = 0.006) and decaffeinated coffee (P for trend = 0.01), and a decreased risk of ALS for high consumption of tea (P for trend = 0.02) and French fries (P for trend = 0.02); however, none of these latter associations remained significant after adjusting for multiple comparisons. CONCLUSIONS: Overall, these results do not provide convincing evidence that the investigated food items are related to ALS mortality. The association observed between chicken consumption and ALS mortality should be assessed in other studies.
BACKGROUND: Several dietary factors have been associated with risk of amyotrophic lateral sclerosis (ALS) in case-control studies, but no prospective studies have investigated diet and ALS. METHODS: We prospectively assessed the association of selected foods and beverages with ALSmortality among participants of the Cancer Prevention Study II, a cohort of over 1 million men and women enrolled in 1982. Habitual diet was assessed with a 44-item food frequency questionnaire. Participant follow-up was conducted from 1989 through 2002 for ALSmortality. RESULTS: During the follow-up period, 862 cohort participants died of ALS. The strongest finding was an inverse association between chicken consumption and risk of ALS (P for trend = 0.0006). We also observed an increased risk of ALS among study participants with a high consumption of brown rice/whole wheat/barley (P for trend = 0.006) and decaffeinated coffee (P for trend = 0.01), and a decreased risk of ALS for high consumption of tea (P for trend = 0.02) and French fries (P for trend = 0.02); however, none of these latter associations remained significant after adjusting for multiple comparisons. CONCLUSIONS: Overall, these results do not provide convincing evidence that the investigated food items are related to ALSmortality. The association observed between chicken consumption and ALSmortality should be assessed in other studies.
Authors: Peter E A Ash; Uma Dhawan; Samantha Boudeau; Shuwen Lei; Yari Carlomagno; Mark Knobel; Louloua F A Al Mohanna; Steven R Boomhower; M Christopher Newland; David H Sherr; Benjamin Wolozin Journal: Toxicol Sci Date: 2019-01-01 Impact factor: 4.849
Authors: Peter E A Ash; Elizabeth A Stanford; Ali Al Abdulatif; Alejandra Ramirez-Cardenas; Heather I Ballance; Samantha Boudeau; Amanda Jeh; James M Murithi; Yorghos Tripodis; George J Murphy; David H Sherr; Benjamin Wolozin Journal: Mol Neurodegener Date: 2017-05-05 Impact factor: 14.195
Authors: Tommaso Filippini; Maria Fiore; Marina Tesauro; Carlotta Malagoli; Michela Consonni; Federica Violi; Elisa Arcolin; Laura Iacuzio; Gea Oliveri Conti; Antonio Cristaldi; Pietro Zuccarello; Elisabetta Zucchi; Letizia Mazzini; Fabrizio Pisano; Ileana Gagliardi; Francesco Patti; Jessica Mandrioli; Margherita Ferrante; Marco Vinceti Journal: Int J Environ Res Public Health Date: 2020-01-30 Impact factor: 3.390