AIM: To compare the effects of treatment of H pylori-infected individuals with the effects of treatment of individuals as well as all H pylori-infected family members. METHODS:H pylori-positive patients with similar demographic specifications were prospectively randomized with respect to treatment, with a triple regimen of either patients and all H pylori-positive family members living togetherI (group I) or patients only (group II). Nine months after treatment, all patients were assessed for H pylori positivity. RESULTS: There were 70 H pylori-positive patients in each group; patients in groups I and II lived with 175 and 190 H pylori-positive relatives, respectively. Age, sex and H pylori positivity rate were similar in both groups of relatives. Nine months after 14 d standard triple therapy, H pylori positivity was 7.1% in group I patients and 38.6% in group II patients [P < 0.01, OR = 8.61 95% confidence interval (CI): 2.91-22.84]. CONCLUSION: The present results indicate bad environmental hygienic conditions and close intra-familial relationships are important in H pylori contamination. These findings indicate all family members of H pylori-positive individuals should be assessed for H pylori positivity, particularly in developing countries where H pylori prevalence is high; they also suggest patients, their spouses and all H pylori-positive family members of H pylori-positive individuals should be treated for H pylori infection.
RCT Entities:
AIM: To compare the effects of treatment of H pylori-infected individuals with the effects of treatment of individuals as well as all H pylori-infected family members. METHODS: H pylori-positive patients with similar demographic specifications were prospectively randomized with respect to treatment, with a triple regimen of either patients and all H pylori-positive family members living togetherI (group I) or patients only (group II). Nine months after treatment, all patients were assessed for H pylori positivity. RESULTS: There were 70 H pylori-positive patients in each group; patients in groups I and II lived with 175 and 190 H pylori-positive relatives, respectively. Age, sex and H pylori positivity rate were similar in both groups of relatives. Nine months after 14 d standard triple therapy, H pylori positivity was 7.1% in group I patients and 38.6% in group II patients [P < 0.01, OR = 8.61 95% confidence interval (CI): 2.91-22.84]. CONCLUSION: The present results indicate bad environmental hygienic conditions and close intra-familial relationships are important in H pylori contamination. These findings indicate all family members of H pylori-positive individuals should be assessed for H pylori positivity, particularly in developing countries where H pylori prevalence is high; they also suggest patients, their spouses and all H pylori-positive family members of H pylori-positive individuals should be treated for H pylori infection.
Authors: Linda Morris Brown; Terry L Thomas; Jun-Ling Ma; Yun-Sheng Chang; Wei-cheng You; Wei-dong Liu; Lian Zhang; David Pee; Mitchell H Gail Journal: Int J Epidemiol Date: 2002-06 Impact factor: 7.196
Authors: Kevin F Boehnke; Manuel Valdivieso; Alejandro Bussalleu; Rachael Sexton; Kathryn C Thompson; Soledad Osorio; Italo Novoa Reyes; John J Crowley; Laurence H Baker; Chuanwu Xi Journal: Infect Drug Resist Date: 2017-03-10 Impact factor: 4.003
Authors: Traci L Testerman; Cristina Semino-Mora; Jennifer A Cann; Beidi Qiang; Edsel A Peña; Hui Liu; Cara H Olsen; Haiying Chen; Susan E Appt; Jay R Kaplan; Thomas C Register; D Scott Merrell; Andre Dubois Journal: PLoS One Date: 2019-09-06 Impact factor: 3.240