BACKGROUND: A progressive reduction in peritubular capillary flow is observed in chronic kidney disease (CKD) patients as the disease severity progresses. This suggests an altered vascular homeostasis in CKD patients, but such a defective mechanism needs to be verified. METHODS: To study the vascular injury as reflected by circulating endothelial cell (CEC), the balance between angiogenic factor, vascular endothelial growth factor (VEGF), and antiangiogenic factor, endostatin. RESULTS: A deficient VEGF was observed, whereas the value of endostatin and CEC were abnormally elevated in CKD patients. DISCUSSION: Enhanced CEC reflects an increased activity of vascular injury. A deficient VEGF in the presence of enhanced antiangiogenesis (endostatin) implies a defective angiogenesis. This may explain the progressive nature of renal microvascular disease observed in late stage of CKD patients.
BACKGROUND: A progressive reduction in peritubular capillary flow is observed in chronic kidney disease (CKD) patients as the disease severity progresses. This suggests an altered vascular homeostasis in CKDpatients, but such a defective mechanism needs to be verified. METHODS: To study the vascular injury as reflected by circulating endothelial cell (CEC), the balance between angiogenic factor, vascular endothelial growth factor (VEGF), and antiangiogenic factor, endostatin. RESULTS: A deficient VEGF was observed, whereas the value of endostatin and CEC were abnormally elevated in CKDpatients. DISCUSSION: Enhanced CEC reflects an increased activity of vascular injury. A deficient VEGF in the presence of enhanced antiangiogenesis (endostatin) implies a defective angiogenesis. This may explain the progressive nature of renal microvascular disease observed in late stage of CKDpatients.
Authors: Erika Guise; Jason E Engel; Maxx L Williams; Fakhri Mahdi; Gene L Bidwell; Alejandro R Chade Journal: Am J Physiol Renal Physiol Date: 2019-03-20
Authors: Jing Chen; L Lee Hamm; Myra A Kleinpeter; Fred Husserl; Islam Enver Khan; Chung-Shiuan Chen; Yanxi Liu; Katherine T Mills; Chuan He; Nader Rifai; Eric E Simon; Jiang He Journal: Am J Nephrol Date: 2012-03-27 Impact factor: 3.754
Authors: Rukshana C Shroff; Karen L Price; Maria Kolatsi-Joannou; Alexandra F Todd; David Wells; John Deanfield; Richard J Johnson; Lesley Rees; Adrian S Woolf; David A Long Journal: PLoS One Date: 2013-02-08 Impact factor: 3.240