PURPOSE: The effect of AcrySof filter (UV light-filtering chromophore; Alcon) and AcrySof Natural filter (UV- and blue light-filtering chromophores) on blue light-induced apoptosis in human retinal pigment epithelial (RPE) cells was evaluated. DESIGN: Laboratory investigation CLINICAL RELEVANCE: Acrysof Natural filter reduces the blue-light toxicity in RPE cells and may have a positive impact on age-related macular degeneration (AMD). METHODS: RPE cells were exposed to blue light (430-450 nm) in the presence of either the AcrySof (UV only) filter or Acrysof Natural (UV and blue light) filter for 10 days. The rate of apoptosis was analyzed. RESULTS: Blue light induced significant apoptosis in RPE cells. AcrySof Natural filter significantly reduced the blue light-induced apoptosis when compared to AcrySof filter. The amount of blue-light energy reaching the cells with the AcrySof filter was 4.25 mW/cm(2) and with the AcrySof Natural filter was 2.5 mW/cm(2). CONCLUSIONS: AcrySof Natural filter significantly reduced blue light-induced apoptosis. This was most likely due to its filtering effect on blue wavelength light, which reduces the energy that reaches the cells. In patients with cataract who are at a high risk for AMD, the implantation of a blue light-filtering intraocular lens may be considered.
PURPOSE: The effect of AcrySof filter (UV light-filtering chromophore; Alcon) and AcrySof Natural filter (UV- and blue light-filtering chromophores) on blue light-induced apoptosis in humanretinal pigment epithelial (RPE) cells was evaluated. DESIGN: Laboratory investigation CLINICAL RELEVANCE: Acrysof Natural filter reduces the blue-light toxicity in RPE cells and may have a positive impact on age-related macular degeneration (AMD). METHODS: RPE cells were exposed to blue light (430-450 nm) in the presence of either the AcrySof (UV only) filter or Acrysof Natural (UV and blue light) filter for 10 days. The rate of apoptosis was analyzed. RESULTS: Blue light induced significant apoptosis in RPE cells. AcrySof Natural filter significantly reduced the blue light-induced apoptosis when compared to AcrySof filter. The amount of blue-light energy reaching the cells with the AcrySof filter was 4.25 mW/cm(2) and with the AcrySof Natural filter was 2.5 mW/cm(2). CONCLUSIONS: AcrySof Natural filter significantly reduced blue light-induced apoptosis. This was most likely due to its filtering effect on blue wavelength light, which reduces the energy that reaches the cells. In patients with cataract who are at a high risk for AMD, the implantation of a blue light-filtering intraocular lens may be considered.
Authors: Bernard F Godley; Farrukh A Shamsi; Fong-Qi Liang; Stuart G Jarrett; Sallyanne Davies; Mike Boulton Journal: J Biol Chem Date: 2005-03-29 Impact factor: 5.157
Authors: Jie Jin Wang; Ronald Klein; Wayne Smith; Barbara E K Klein; Sandy Tomany; Paul Mitchell Journal: Ophthalmology Date: 2003-10 Impact factor: 12.079
Authors: Wing Yan Yu; Samantha Sze Wan Shan; Yamunadevi Lakshmanan; Francisca Siu Yin Wong; Kai Yip Choi; Henry Ho Lung Chan Journal: PLoS One Date: 2022-05-24 Impact factor: 3.752
Authors: James A Davison; Anil S Patel; Joao P Cunha; Jim Schwiegerling; Orkun Muftuoglu Journal: Graefes Arch Clin Exp Ophthalmol Date: 2011-05-17 Impact factor: 3.117
Authors: Francesco Parmeggiani; Giovanni Sato; Katia De Nadai; Mario R Romano; Andrea Binotto; Ciro Costagliola Journal: Curr Genomics Date: 2011-06 Impact factor: 2.236
Authors: Natalia Vila; Aya Siblini; Evangelina Esposito; Vasco Bravo-Filho; Pablo Zoroquiain; Sultan Aldrees; Patrick Logan; Lluis Arias; Miguel N Burnier Journal: BMC Ophthalmol Date: 2017-11-02 Impact factor: 2.209