OBJECTIVE: The aim of this study was to assess the cellular proliferation rate of major and minor salivary gland mucoepidermoid carcinomas (MECs) by quantitative analysis of AgNOR and to determine its relation to histopathologic grading. STUDY DESIGN: Thirty-five cases of major and minor salivary gland MECs, were retrieved and graded according to the AFIP grading schema. The mean AgNOR count was calculated for all cases. RESULTS: Mean AgNOR counts were 0.64 +/- 0.15 in low-, 1.04 +/- 0.21 in intermediate-, and 1.42 +/- 0.23 in high-grade MECs. A significant difference was observed in the mean AgNOR counts among the 3 groups (P < .001). CONCLUSION: It can be suggested that the AgNOR technique can be applied on routine histological samples to assess the growth potential of MECs. However, its prognostic value should be validated with clinical studies and survival analyses.
OBJECTIVE: The aim of this study was to assess the cellular proliferation rate of major and minor salivary gland mucoepidermoid carcinomas (MECs) by quantitative analysis of AgNOR and to determine its relation to histopathologic grading. STUDY DESIGN: Thirty-five cases of major and minor salivary gland MECs, were retrieved and graded according to the AFIP grading schema. The mean AgNOR count was calculated for all cases. RESULTS: Mean AgNOR counts were 0.64 +/- 0.15 in low-, 1.04 +/- 0.21 in intermediate-, and 1.42 +/- 0.23 in high-grade MECs. A significant difference was observed in the mean AgNOR counts among the 3 groups (P < .001). CONCLUSION: It can be suggested that the AgNOR technique can be applied on routine histological samples to assess the growth potential of MECs. However, its prognostic value should be validated with clinical studies and survival analyses.
Authors: João Adolfo Costa Hanemann; Marta Miyazawa; Mireile São Geraldo dos Santos Souza Journal: J Appl Oral Sci Date: 2011 May-Jun Impact factor: 2.698
Authors: Amr Ibrahim; Emad Alqalshy; Ahmed Abdel-Shakour Abdel-Hafiz; Kamal Abd El-Rahman; Magdy Alazzazi Journal: Diagnostics (Basel) Date: 2022-02-03
Authors: Leszek Gottwald; Marian Danilewicz; Wojciech Fendler; Jacek Suzin; Michal Spych; Janusz Piekarski; Wieslaw Tylinski; Justyna Chalubinska; Katarzyna Topczewska-Tylinska; Aleksandra Cialkowska-Rysz Journal: Arch Med Sci Date: 2013-08-12 Impact factor: 3.318