BACKGROUND: The aim of the current study is to estimate the association between parenting factors derived from the Parental Bonding Instrument (PBI) and a lifetime DSM-IV diagnosis of OCD. METHOD: Data were from approximately 1200 adults from 465 families assessed as part of a large family and genetic study of OCD. The association of three parenting factors, for fathers and mothers, with offspring OCD status were examined; analyses were stratified by parental OCD status and family loading for OCD (multiplex versus sporadic). RESULTS: Three factors were derived by principal components factor analysis of the PBI (maternal and paternal care, overprotection and control). Maternal overprotection was associated with OCD in offspring with familial OCD (familial cases) but only if neither parent was affected with OCD, which suggests independent but additive environmental and genetic risk (OR = 5.9, 95% CI 1.2, 29.9, p = 0.031). Paternal care was a protective factor in those not at high genetic risk (sporadic cases) (OR = 0.2, 95% CI 0.0, 0.8, p = 0.027). Maternal overprotection was also associated with offspring OCD in sporadic families (OR = 2.9, 95% CI 1.3, 6.6, p = 0.012). The finding that parental overprotection and care were not associated with offspring OCD when at least one parent had OCD addressed directly the hypothesis of maternal or paternal OCD adversely impacting parenting. CONCLUSIONS: This study provides evidence that aspects of parenting may contribute to the development of OCD among offspring. Prospective studies of children at risk for OCD are needed to explore the direction of causality.
BACKGROUND: The aim of the current study is to estimate the association between parenting factors derived from the Parental Bonding Instrument (PBI) and a lifetime DSM-IV diagnosis of OCD. METHOD: Data were from approximately 1200 adults from 465 families assessed as part of a large family and genetic study of OCD. The association of three parenting factors, for fathers and mothers, with offspring OCD status were examined; analyses were stratified by parental OCD status and family loading for OCD (multiplex versus sporadic). RESULTS: Three factors were derived by principal components factor analysis of the PBI (maternal and paternal care, overprotection and control). Maternal overprotection was associated with OCD in offspring with familial OCD (familial cases) but only if neither parent was affected with OCD, which suggests independent but additive environmental and genetic risk (OR = 5.9, 95% CI 1.2, 29.9, p = 0.031). Paternal care was a protective factor in those not at high genetic risk (sporadic cases) (OR = 0.2, 95% CI 0.0, 0.8, p = 0.027). Maternal overprotection was also associated with offspring OCD in sporadic families (OR = 2.9, 95% CI 1.3, 6.6, p = 0.012). The finding that parental overprotection and care were not associated with offspring OCD when at least one parent had OCD addressed directly the hypothesis of maternal or paternal OCD adversely impacting parenting. CONCLUSIONS: This study provides evidence that aspects of parenting may contribute to the development of OCD among offspring. Prospective studies of children at risk for OCD are needed to explore the direction of causality.
Authors: Joseph A Himle; Robert Joseph Taylor; Ann W Nguyen; Monnica T Williams; Karen D Lincoln; Harry Owen Taylor; Linda M Chatters Journal: Behav Ther (N Y N Y) Date: 2017-03
Authors: David Chen; O Joseph Bienvenu; Janice Krasnow; Ying Wang; Marco A Grados; Bernadette Cullen; Fernando S Goes; Brion Maher; Benjamin D Greenberg; Nicole C McLaughlin; Steven A Rasmussen; Abby J Fyer; James A Knowles; James T McCracken; John Piacentini; Dan Geller; David L Pauls; S Evelyn Stewart; Dennis L Murphy; Yin-Yao Shugart; Mark A Riddle; Gerald Nestadt; Jack Samuels Journal: Compr Psychiatry Date: 2016-11-14 Impact factor: 3.735
Authors: Anouk den Braber; Dennis van 't Ent; Danielle C Cath; Judith Wagner; Dorret I Boomsma; Eco J C de Geus Journal: Brain Date: 2010-09-07 Impact factor: 13.501