Literature DB >> 18299100

Early intralipid therapy may have prevented bupivacaine-associated cardiac arrest.

Thomas McCutchen1, J C Gerancher.   

Abstract

OBJECTIVE: Local anesthetic-induced cardiotoxicity remains a complication of regional anesthesia, with the potential to result in cardiac arrest refractory to resuscitation. Successful resuscitation using Intralipid (Baxter Pharmaceuticals by Fresenius Kabi, Uppsala, Sweden), has been reported in 2 patients with bupivacaine-induced cardiac arrest. CASE REPORT: We report another case for which Intralipid was used as part of a successful resuscitation in a patient with local anesthetic-induced cardiotoxicity.
CONCLUSIONS: Early treatment with Intralipid may help prevent cardiac arrest and speed successful resuscitation efforts.

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Year:  2008        PMID: 18299100     DOI: 10.1016/j.rapm.2007.09.006

Source DB:  PubMed          Journal:  Reg Anesth Pain Med        ISSN: 1098-7339            Impact factor:   6.288


  11 in total

1.  Fatty-acid oxidation and calcium homeostasis are involved in the rescue of bupivacaine-induced cardiotoxicity by lipid emulsion in rats.

Authors:  Parisa Partownavid; Soban Umar; Jingyuan Li; Siamak Rahman; Mansoureh Eghbali
Journal:  Crit Care Med       Date:  2012-08       Impact factor: 7.598

2.  Free Fatty Acid Receptor G-protein-coupled Receptor 40 Mediates Lipid Emulsion-induced Cardioprotection.

Authors:  Soban Umar; Jingyuan Li; Kyle Hannabass; Mylene Vaillancourt; Christine M Cunningham; Shayan Moazeni; Aman Mahajan; Mansoureh Eghbali
Journal:  Anesthesiology       Date:  2018-07       Impact factor: 7.892

Review 3.  Clinical applications of intravenous lipid emulsion therapy.

Authors:  Sam H Muller; James H Diaz; Alan David Kaye
Journal:  J Anesth       Date:  2015-06-07       Impact factor: 2.078

4.  [Bupivacaine toxicity and propofol anesthesia : animal study on intravascular bupivacaine injection].

Authors:  J Mauch; A P N Kutter; O Martin Jurado; N Spielmann; A Frotzler; R Bettschart-Wolfensberger; M Weiss
Journal:  Anaesthesist       Date:  2011-07-03       Impact factor: 1.041

Review 5.  Lipid emulsion infusion: resuscitation for local anesthetic and other drug overdose.

Authors:  Guy L Weinberg
Journal:  Anesthesiology       Date:  2012-07       Impact factor: 7.892

6.  LIPAEMIC report: results of clinical use of intravenous lipid emulsion in drug toxicity reported to an online lipid registry.

Authors:  Grant Cave; Martyn Harvey; Johann Willers; David Uncles; Tim Meek; John Picard; Guy Weinberg
Journal:  J Med Toxicol       Date:  2014-06

Review 7.  Intravenous lipid emulsion in clinical toxicology.

Authors:  Leelach Rothschild; Sarah Bern; Sarah Oswald; Guy Weinberg
Journal:  Scand J Trauma Resusc Emerg Med       Date:  2010-10-05       Impact factor: 2.953

Review 8.  Lipid Emulsion for Treating Local Anesthetic Systemic Toxicity.

Authors:  Seong-Ho Ok; Jeong-Min Hong; Soo Hee Lee; Ju-Tae Sohn
Journal:  Int J Med Sci       Date:  2018-05-14       Impact factor: 3.738

9.  Lipid emulsion-mediated reversal of toxic-dose aminoamide local anesthetic-induced vasodilation in isolated rat aorta.

Authors:  Seong-Ho Ok; Jeong Yeol Han; Soo Hee Lee; Il-Woo Shin; Heon Keun Lee; Young-Kyun Chung; Mun-Jeoung Choi; Ju-Tae Sohn
Journal:  Korean J Anesthesiol       Date:  2013-04-22

10.  Intravenous lipid emulsion modifies synaptic transmission in hippocampal CA1 pyramidal neurons after bupivacaine-induced central nervous system toxicity.

Authors:  Hao Nie; Zhixia Bai; Zhenzhou Li; Li Yan; Xue-Xin Chen
Journal:  J Neurochem       Date:  2020-01-07       Impact factor: 5.372

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