Lin Liu1, Min Zhang, Ping Zou. 1. Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Abstract
AIM: The present study was designed to investigate the expression of Polo-like kinase 1 (PLK1) and survivin in non-Hodgkinos lymphoma (NHL). METHODS: The expression of PLK1 and survivin were detected with immunohistochemical techniques. RESULTS: The expression rate of PLK1 and survivin were 63.6% (56/88) and 79.5% (70/88) in NHL, respectively. PLK1 expression correlated with systemic symptoms, lactate dehydrogenase levels, and international prognostic index scores in B-NHL and T-NHL, while survivin did not. CONCLUSION: PLK1 and survivin are both overexpressed in NHL. There is a significant relationship between the overexpression of PLK1 and clinical features.
AIM: The present study was designed to investigate the expression of Polo-like kinase 1 (PLK1) and survivin in non-Hodgkinos lymphoma (NHL). METHODS: The expression of PLK1 and survivin were detected with immunohistochemical techniques. RESULTS: The expression rate of PLK1 and survivin were 63.6% (56/88) and 79.5% (70/88) in NHL, respectively. PLK1 expression correlated with systemic symptoms, lactate dehydrogenase levels, and international prognostic index scores in B-NHL and T-NHL, while survivin did not. CONCLUSION:PLK1 and survivin are both overexpressed in NHL. There is a significant relationship between the overexpression of PLK1 and clinical features.
Authors: Zhi-qiang Wang; Jun Zhao; Jin Zeng; Kai-jie Wu; Yu-le Chen; Xin-yang Wang; Luke S Chang; Da-lin He Journal: Acta Pharmacol Sin Date: 2011-10-24 Impact factor: 6.150