| Literature DB >> 18298083 |
Stephen J Benkovic1, Gordon G Hammes, Sharon Hammes-Schiffer.
Abstract
The concept is developed that enzyme mechanisms should be viewed as "catalytic networks" with multiple conformations that occur serially and in parallel in the mechanism. These coupled ensembles of conformations require a multi-dimensional standard free-energy surface that is very "rugged", containing multiple minima and transition states. Experimental and theoretical evidence is presented to support this concept.Mesh：
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Year: 2008 PMID： 18298083 DOI： 10.1021/bi800049z
Source DB: PubMed Journal: Biochemistry ISSN： 0006-2960 Impact factor: 3.162