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Literature DB >> 18297660

Improving oral bioavailability of peptides by multiple N-methylation: somatostatin analogues.

Eric Biron¹, Jayanta Chatterjee, Oded Ovadia, Daniel Langenegger, Joseph Brueggen, Daniel Hoyer, Herbert A Schmid, Raz Jelinek, Chaim Gilon, Amnon Hoffman, Horst Kessler.

Abstract

Entities: Chemical

Mesh：

Substances：
Somatostatin

Year: 2008 PMID： 18297660 DOI： 10.1002/anie.200705797

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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64 in total

1. Generating orally active galanin analogues with analgesic activities.

Authors: Charles R Robertson; Timothy H Pruess; Erin Grussendorf; H Steve White; Grzegorz Bulaj
Journal: ChemMedChem Date: 2012-02-28 Impact factor: 3.466

2. Pharmacokinetic and pharmacodynamic evidence for developing an oral formulation of octreotide against gastric mucosal injury.

Authors: Xi-Nuo Li; Tai Rao; Yang-Fan Xu; Kang-Rui Hu; Zhang-Pei Zhu; Hao-Feng Li; Dian Kang; Yu-Hao Shao; Bo-Yu Shen; Xiao-Xi Yin; Lin Xie; Guang-Ji Wang; Yan Liang
Journal: Acta Pharmacol Sin Date: 2017-11-30 Impact factor: 6.150

3. EPSA: A Novel Supercritical Fluid Chromatography Technique Enabling the Design of Permeable Cyclic Peptides.

Authors: Gilles H Goetz; Laurence Philippe; Michael J Shapiro
Journal: ACS Med Chem Lett Date: 2014-08-04 Impact factor: 4.345

4. Permeability of Cyclic Peptide Macrocycles and Cyclotides and Their Potential as Therapeutics.

Authors: Spiros Liras; Kim F Mcclure
Journal: ACS Med Chem Lett Date: 2019-06-14 Impact factor: 4.345

5. Macrocyclic peptides: Tying up loose ends.

Authors: Fumito Saito; Jeffrey W Bode
Journal: Nat Chem Date: 2016-11-22 Impact factor: 24.427

6. Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance().

Authors: Arthur C Rand; Siegfried S F Leung; Heather Eng; Charles J Rotter; Raman Sharma; Amit S Kalgutkar; Yizhong Zhang; Manthena V Varma; Kathleen A Farley; Bhagyashree Khunte; Chris Limberakis; David A Price; Spiros Liras; Alan M Mathiowetz; Matthew P Jacobson; R Scott Lokey
Journal: Medchemcomm Date: 2012-10 Impact factor: 3.597

Improving oral bioavailability of peptides by multiple N-methylation: somatostatin analogues.

1. Generating orally active galanin analogues with analgesic activities.

2. Pharmacokinetic and pharmacodynamic evidence for developing an oral formulation of octreotide against gastric mucosal injury.

3. EPSA: A Novel Supercritical Fluid Chromatography Technique Enabling the Design of Permeable Cyclic Peptides.

4. Permeability of Cyclic Peptide Macrocycles and Cyclotides and Their Potential as Therapeutics.

5. Macrocyclic peptides: Tying up loose ends.

6. Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance().

Review 7. Impact of physiochemical properties on pharmacokinetics of protein therapeutics.

8. Almiramides A-C: discovery and development of a new class of leishmaniasis lead compounds.

9. Tuning of protease resistance in oligopeptides through N-alkylation.

Review 10. Direct Activation of Bax Protein for Cancer Therapy.