Tsukasa Nozu1, Hiroaki Komiyama. 1. Department of Internal Medicine Shari General Hospital, 41 Aoba-cho, Shari, 099-4117, Japan.
Abstract
BACKGROUND: Asymptomatic esophagitis is not rare in gastroesophageal reflux disease. However, little attention has been given to this disease so far. We evaluated the clinical characteristics of patients with asymptomatic esophagitis and determined the factors associated with this disease. METHODS: A cross-sectional survey was performed of 87 patients with esophagitis, aged 23 to 90 years, diagnosed by endoscopy. We assessed 12 clinical variables at the time of the endoscopy: symptoms, age, sex, severity of esophagitis (Los Angeles classification), grade of gastric mucosal atrophy, presence or absence of Barrett's epithelium and sliding hernia, alcohol, smoking, body-mass index (BMI), comorbid diseases such as hypertension, diabetes and asthma, and medications such as calcium blocker and theophylline. RESULTS: Most patients had grade A or B esophagitis; 64 patients were symptomatic, and the remaining 23 were asymptomatic. In a univariate analysis, the assessed variables sex, BMI, drinking, and smoking (habit and amount of consumption) were associated with asymptomatic esophagitis (P < 0.05). Then, multivariate logistic analysis performed using these four variables demonstrated that sex, BMI, and smoking (habit and number of cigarettes smoked daily) were significantly and in dependently associated with this disease (P < 0.05). CONCLUSIONS: Smoking, male sex, and lower BMI are independent factors associated with asymptomatic esophagitis. Since no information is available on the natural history of this disease, we should pay attention to patients with these characteristics.
BACKGROUND: Asymptomatic esophagitis is not rare in gastroesophageal reflux disease. However, little attention has been given to this disease so far. We evaluated the clinical characteristics of patients with asymptomatic esophagitis and determined the factors associated with this disease. METHODS: A cross-sectional survey was performed of 87 patients with esophagitis, aged 23 to 90 years, diagnosed by endoscopy. We assessed 12 clinical variables at the time of the endoscopy: symptoms, age, sex, severity of esophagitis (Los Angeles classification), grade of gastric mucosal atrophy, presence or absence of Barrett's epithelium and sliding hernia, alcohol, smoking, body-mass index (BMI), comorbid diseases such as hypertension, diabetes and asthma, and medications such as calcium blocker and theophylline. RESULTS: Most patients had grade A or B esophagitis; 64 patients were symptomatic, and the remaining 23 were asymptomatic. In a univariate analysis, the assessed variables sex, BMI, drinking, and smoking (habit and amount of consumption) were associated with asymptomatic esophagitis (P < 0.05). Then, multivariate logistic analysis performed using these four variables demonstrated that sex, BMI, and smoking (habit and number of cigarettes smoked daily) were significantly and in dependently associated with this disease (P < 0.05). CONCLUSIONS: Smoking, male sex, and lower BMI are independent factors associated with asymptomatic esophagitis. Since no information is available on the natural history of this disease, we should pay attention to patients with these characteristics.
Authors: Robert H Paul; Adam M Brickman; Ronald A Cohen; Leanne M Williams; Raymond Niaura; Sakire Pogun; C Richard Clark; John Gunstad; Evian Gordon Journal: J Clin Neurosci Date: 2006-05 Impact factor: 1.961
Authors: M Fein; M P Ritter; T R DeMeester; S Oberg; J H Peters; J A Hagen; C G Bremner Journal: J Gastrointest Surg Date: 1999 Jul-Aug Impact factor: 3.452
Authors: Hashem B El-Serag; Nancy J Petersen; Junaia Carter; David Y Graham; Peter Richardson; Robert M Genta; Linda Rabeneck Journal: Gastroenterology Date: 2004-06 Impact factor: 22.682
Authors: Cadman L Leggett; Eric M Nelsen; Jianmin Tian; Cathy B Schleck; Alan R Zinsmeister; Kelly T Dunagan; G Richard Locke; Kenneth K Wang; Nicholas J Talley; Prasad G Iyer Journal: Mayo Clin Proc Date: 2013-02 Impact factor: 7.616
Authors: Sang Pyo Lee; Kang Nyeong Lee; Oh Young Lee; Hang Lak Lee; Ho Soon Choi; Byung Chul Yoon; Dae Won Jun; Won Sohn; Seung Chul Cho Journal: J Neurogastroenterol Motil Date: 2012-07-10 Impact factor: 4.924