Yajie Wang1, Baoqin Gao. 1. Department of Pediatrics, Beijing TianTan Hospital, Beijing 100050, China. yajienet@yahoo.com.cn
Abstract
OBJECTIVES: To observe the dose-response relationship of intramuscular injections of botulinum toxin A (BTX-A) in the spastic cerebral palsy. METHODS:One hundred fifty cases (age between 2 and 12 years) were randomly divided into three groups. The patients were injected with different dose of BTX-A. The movement function was evaluated with modified Ashworth scale (MAS) and physician's rating scale (PRS) at entry and 1 month after injection. The analyses were conducted with one-way analysis of variance and chi (2) test. RESULTS: The evaluation of MAS and PRS revealed a significant increase of movement function. No statistically significant differences of the side effects among three groups could be demonstrated. CONCLUSIONS: The study suggested that the movement function was more significantly improved with relatively higher dose of BTX-A, which was safe and effective.
RCT Entities:
OBJECTIVES: To observe the dose-response relationship of intramuscular injections of botulinum toxin A (BTX-A) in the spastic cerebral palsy. METHODS: One hundred fifty cases (age between 2 and 12 years) were randomly divided into three groups. The patients were injected with different dose of BTX-A. The movement function was evaluated with modified Ashworth scale (MAS) and physician's rating scale (PRS) at entry and 1 month after injection. The analyses were conducted with one-way analysis of variance and chi (2) test. RESULTS: The evaluation of MAS and PRS revealed a significant increase of movement function. No statistically significant differences of the side effects among three groups could be demonstrated. CONCLUSIONS: The study suggested that the movement function was more significantly improved with relatively higher dose of BTX-A, which was safe and effective.
Authors: Walter Strobl; Tim Theologis; Reinald Brunner; Serdar Kocer; Elke Viehweger; Ignacio Pascual-Pascual; Richard Placzek Journal: Toxins (Basel) Date: 2015-05-11 Impact factor: 4.546