Literature DB >> 18297171

Optimizing paediatric HIV care in Kenya: challenges in early infant diagnosis.

Peter Cherutich1, Irene Inwani, Ruth Nduati, Dorothy Mbori-Ngacha.   

Abstract

PROBLEM: In 2003, the goal of the Kenyan Ministry of Health was to avail antiretroviral treatment (ART) to 50% of the estimated 250 000 eligible individuals by the end of 2005. By July 2005, 45 000 adults and more than 2000 children were on treatment. A study was conducted to determine the barriers to identification of HIV-infected children. APPROACH: Existing government policies were reviewed and the ART register of the Kenya National AIDS Control Programme was used to identify facilities providing ART. This paper reports the findings around diagnosis and staging of HIV infection in children. LOCAL
SETTING: At the time of the study, 58 health facilities were providing ART to children. Only one institution had achieved universal HIV testing in the antenatal clinics. Six facilities systematically followed up HIV-exposed children. HIV antibody testing was not readily available to the children. Although four research centres were capable of carrying out diagnostic HIV polymerase chain reaction (PCR), the services were restricted to research purposes. Other constraints were inadequate physical infrastructure, inadequate systems for quality control in the laboratories and shortage of staff. LESSONS LEARNT: The policy framework to support identification of HIV-infected children had been established, albeit with narrow focus on sick children. The assessment identified the weaknesses in the structures for systematic diagnosis of HIV through laboratory or clinical-based algorithms. The researchers concluded that health staff training and implementation of a systematic standard approach to identification of HIV-infected children is urgently required.

Entities:  

Mesh:

Year:  2008        PMID: 18297171      PMCID: PMC2647375          DOI: 10.2471/blt.07.040402

Source DB:  PubMed          Journal:  Bull World Health Organ        ISSN: 0042-9686            Impact factor:   9.408


  1 in total

1.  Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis.

Authors:  Marie-Louise Newell; Hoosen Coovadia; Marjo Cortina-Borja; Nigel Rollins; Philippe Gaillard; Francois Dabis
Journal:  Lancet       Date:  2004 Oct 2-8       Impact factor: 79.321

  1 in total
  15 in total

1.  Early infant diagnosis and outcomes in HIV-exposed infants at a central and a district hospital, Northern Malawi.

Authors:  N A Phiri; H-Y Lee; L Chilenga; C Mtika; F Sinyiza; O Musopole; R Nyirenda; J K-L Yu; A D Harries
Journal:  Public Health Action       Date:  2017-06-21

2.  Inadequate coordination of maternal and infant HIV services detrimentally affects early infant diagnosis outcomes in Lilongwe, Malawi.

Authors:  Maureen Braun; Mark M Kabue; Eric D McCollum; Saeed Ahmed; Maria Kim; Leela Aertker; Marko Chirwa; Michael Eliya; Innocent Mofolo; Irving Hoffman; Peter N Kazembe; Charles van der Horst; Mark W Kline; Mina C Hosseinipour
Journal:  J Acquir Immune Defic Syndr       Date:  2011-04-15       Impact factor: 3.731

3.  Implementation and Operational Research: Effects of Antenatal Care and HIV Treatment Integration on Elements of the PMTCT Cascade: Results From the SHAIP Cluster-Randomized Controlled Trial in Kenya.

Authors:  Janet M Turan; Maricianah Onono; Rachel L Steinfeld; Starley B Shade; Kevin Owuor; Sierra Washington; Elizabeth A Bukusi; Marta L Ackers; Jackson Kioko; Evelyn C Interis; Craig R Cohen
Journal:  J Acquir Immune Defic Syndr       Date:  2015-08-15       Impact factor: 3.731

4.  World Health Organization generic protocol to assess drug-resistant HIV among children <18 months of age and newly diagnosed with HIV in resource-limited countries.

Authors:  Silvia Bertagnolio; Martina Penazzato; Michael R Jordan; Deborah Persaud; Lynne M Mofenson; Diane E Bennett
Journal:  Clin Infect Dis       Date:  2012-05       Impact factor: 9.079

5.  Early HIV-1 diagnosis using in-house real-time PCR amplification on dried blood spots for infants in remote and resource-limited settings.

Authors:  Nicole Ngo-Giang-Huong; Woottichai Khamduang; Baptiste Leurent; Intira Collins; Issaren Nantasen; Pranee Leechanachai; Wasna Sirirungsi; Aram Limtrakul; Tasana Leusaree; Anne Marie Comeau; Marc Lallemant; Gonzague Jourdain
Journal:  J Acquir Immune Defic Syndr       Date:  2008-12-15       Impact factor: 3.731

6.  HIV testing: current practice and future directions.

Authors:  Peter Cherutich; Rebecca Bunnell; Jonathan Mermin
Journal:  Curr HIV/AIDS Rep       Date:  2013-06       Impact factor: 5.071

7.  If you text them, they will come: using the HIV infant tracking system to improve early infant diagnosis quality and retention in Kenya.

Authors:  Sarah Finocchario-Kessler; Brad J Gautney; Samoel Khamadi; Vincent Okoth; Kathy Goggin; Jennifer K Spinler; Anne Mwangi; Davies Kimanga; Kristine F Clark; Helen D Olungae; Geoffrey A Preidis
Journal:  AIDS       Date:  2014-07       Impact factor: 4.177

8.  Performance of clinical algorithms for HIV-1 diagnosis and antiretroviral initiation among HIV-1-exposed children aged less than 18 months in Kenya.

Authors:  Irene Inwani; Dorothy Mbori-Ngacha; Ruth Nduati; Elizabeth Obimbo; Dalton Wamalwa; Grace John-Stewart; Carey Farquhar
Journal:  J Acquir Immune Defic Syndr       Date:  2009-04-15       Impact factor: 3.731

9.  Barriers to Initiation of Pediatric HIV Treatment in Uganda: A Mixed-Method Study.

Authors:  T Sonia Boender; Kim C E Sigaloff; Joshua Kayiwa; Victor Musiime; Job C J Calis; Raph L Hamers; Lillian Katumba Nakatudde; Elizabeth Khauda; Andrew Mukuye; James Ditai; Sibyl P Geelen; Peter Mugyenyi; Tobias F Rinke de Wit; Cissy Kityo
Journal:  AIDS Res Treat       Date:  2012-02-06

10.  Missed opportunities for early infant HIV diagnosis: results of a national study in South Africa.

Authors:  Selamawit A Woldesenbet; Debra Jackson; Ameena E Goga; Siobhan Crowley; Tanya Doherty; Mary M Mogashoa; Thu-Ha Dinh; Gayle G Sherman
Journal:  J Acquir Immune Defic Syndr       Date:  2015-03-01       Impact factor: 3.731

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