Literature DB >> 18296703

Overdominance in the human genome and olfactory receptor activity.

Santos Alonso1, Saioa López, Neskuts Izagirre, Concepción de la Rúa.   

Abstract

We investigate the contribution of overdominance to the maintenance of polymorphism in the human genome during the recent evolution of our species. Using the HapMap genotypic information, we have detected that the Gene Ontology term "olfactory receptor activity" is a molecular function overrepresented in genes that have SNPs (Single Nucleotide Polymorphisms) showing higher than expected number of heterozygotes in the HapMap populations. Our results suggest that the diversity of a subset of human olfactory receptors (ORs) may have been maintained by balancing selection, in the form of overdominance. This observation may suggest that the loss of OR genes during the evolution of the human lineage may have been accompanied by an increased capability to discriminate odorants with closely similar structures.

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Year:  2008        PMID： 18296703     DOI： 10.1093/molbev/msn049

Source DB:  PubMed          Journal:  Mol Biol Evol        ISSN： 0737-4038            Impact factor:   16.240


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