Literature DB >> 1829644

Cross-helix separation of tropomyosin molecules in acto-tropomyosin as determined by neutron scattering.

D B Bivin1, D B Stone, D K Schneider, R A Mendelson.   

Abstract

The cross-helix separation of Tm molecules in acto-tropomyosin has been determined using neutron scattering. Deuterated Dictyostelium discoideum actin was density matched in a 93% D2O buffer so that effectively only the protonated tropomyosin was "visible" to neutrons. Analysis of the solution scattering pattern in the region of the first oscillation yielded a value for the cross-helix separation of 7.9 +/- 0.3 nm. The implications of this value for the mechanism of the regulation of muscle contraction are discussed in light of recent results by others.

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Year:  1991        PMID： 1829644      PMCID： PMC1281253          DOI： 10.1016/S0006-3495(91)82300-1

Source DB:  PubMed          Journal:  Biophys J        ISSN： 0006-3495            Impact factor:   4.033


  23 in total

1.  Atomic model of the actin filament.

Authors:  K C Holmes; D Popp; W Gebhard; W Kabsch
Journal:  Nature       Date:  1990-09-06       Impact factor: 49.962

2.  Comparison of the structure of myosin subfragment 1 bound to actin and free in solution. A neutron scattering study using actin made "invisible" by deuteration.

Authors:  P M Curmi; D B Stone; D K Schneider; J A Spudich; R A Mendelson
Journal:  J Mol Biol       Date:  1988-10-05       Impact factor: 5.469

3.  Preparation of deuterated actin from Dictyostelium discoideum.

Authors:  D B Stone; P M Curmi; R A Mendelson
Journal:  Methods Cell Biol       Date:  1987       Impact factor: 1.441

4.  Construction of an atomic model for tropomyosin and implications for interactions with actin.

Authors:  G N Phillips
Journal:  J Mol Biol       Date:  1986-11-05       Impact factor: 5.469

5.  Dual effects of tropomyosin and troponin-tropomyosin on actomyosin subfragment 1 ATPase.

Authors:  S S Lehrer; E P Morris
Journal:  J Biol Chem       Date:  1982-07-25       Impact factor: 5.157

6.  Cooperative turning on of myosin subfragment 1 adenosinetriphosphatase activity by the troponin-tropomyosin-actin complex.

Authors:  D L Williams; L E Greene; E Eisenberg
Journal:  Biochemistry       Date:  1988-09-06       Impact factor: 3.162

7.  Structure of myosin subfragment 1 from low-angle X-ray scattering.

Authors:  R Mendelson; K M Kretzschmar
Journal:  Biochemistry       Date:  1980-08-19       Impact factor: 3.162

8.  Troponin and its interactions with tropomyosin. An electron microscope study.

Authors:  P F Flicker; G N Phillips; C Cohen
Journal:  J Mol Biol       Date:  1982-12-05       Impact factor: 5.469

9.  Potentiated state of the tropomyosin actin filament and nucleotide-containing myosin subfragment 1.

Authors:  J M Murray; M K Knox; C E Trueblood; A Weber
Journal:  Biochemistry       Date:  1982-03-02       Impact factor: 3.162

10.  Structural relationships of actin, myosin, and tropomyosin revealed by cryo-electron microscopy.

Authors:  R A Milligan; P F Flicker
Journal:  J Cell Biol       Date:  1987-07       Impact factor: 10.539
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  3 in total

Review 1.  Vertebrate tropomyosin: distribution, properties and function.

Authors:  S V Perry
Journal:  J Muscle Res Cell Motil       Date:  2001       Impact factor: 2.698

Review 2.  Tropomyosin dynamics.

Authors:  Mohammed El-Mezgueldi
Journal:  J Muscle Res Cell Motil       Date:  2014-02-09       Impact factor: 2.698

3.  Tropomyosin dynamics during cardiac muscle contraction as governed by a multi-well energy landscape.

Authors:  Yasser Aboelkassem; Natalia Trayanova
Journal:  Prog Biophys Mol Biol       Date:  2018-08-23       Impact factor: 3.667
  3 in total

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