| Literature DB >> 18296050 |
Chiaki Ohara1, Ryouko Takahashi, Tatsunori Miyagawa, Yuichi Yoshimura, Atsushi Kato, Isao Adachi, Hiroki Takahata.
Abstract
A highly practicable synthesis of both enantiomers of 3-hydroxypipecolic acid derivatives 1, 2, 3, 4 is described. Screening of these molecules for glycosidase inhibition has been examined. Compound 3 was shown to be a potent inhibitor of beta-N-acetylglucosaminidase as well as Escherichia coli beta-glucuronidase.Entities:
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Year: 2008 PMID： 18296050 DOI： 10.1016/j.bmcl.2008.02.028
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823